Realizing the potential of blockchain technologies in genomics

Simple item page
buir.contributor.authorÖzercan, Halil İbrahim
buir.contributor.authorAyday, Erman
buir.contributor.authorAlkan, Can
dc.citation.epage1263en_US
dc.citation.issueNumber9en_US
dc.citation.spage1255en_US
dc.citation.volumeNumber28en_US
dc.contributor.authorÖzercan, Halil İbrahimen_US
dc.contributor.authorİleri, A. M.en_US
dc.contributor.authorAyday, Ermanen_US
dc.contributor.authorAlkan, Canen_US
dc.date.accessioned2019-02-21T16:03:51Z
dc.date.available2019-02-21T16:03:51Z
dc.date.issued2018en_US
dc.departmentDepartment of Computer Engineeringen_US
dc.description.abstractGenomics data introduce a substantial computational burden as well as data privacy and ownership issues. Data sets generated by high-throughput sequencing platforms require immense amounts of computational resources to align to reference genomes and to call and annotate genomic variants. This problem is even more pronounced if reanalysis is needed for new versions of reference genomes, which may impose high loads to existing computational infrastructures. Additionally, after the compute-intensive analyses are completed, the results are either kept in centralized repositories with access control, or distributed among stakeholders using standard file transfer protocols. This imposes two main problems: (1) Centralized servers become gatekeepers of the data, essentially acting as an unnecessary mediator between the actual data owners and data users; and (2) servers may create single points of failure both in terms of service availability and data privacy. Therefore, there is a need for secure and decentralized platforms for data distribution with user-level data governance. A new technology, blockchain, may help ameliorate some of these problems. In broad terms, the blockchain technology enables decentralized, immutable, incorruptible public ledgers. In this Perspective, we aim to introduce current developments toward using blockchain to address several problems in omics, and to provide an outlook of possible future implications of the blockchain technology to life sciences.
dc.description.provenanceMade available in DSpace on 2019-02-21T16:03:51Z (GMT). No. of bitstreams: 1 Bilkent-research-paper.pdf: 222869 bytes, checksum: 842af2b9bd649e7f548593affdbafbb3 (MD5) Previous issue date: 2018en
dc.description.sponsorshiphelpful discussions in using blockchain technology in genomics. We also thank N. Lack and M. Somel for their feedback in potential uses of the blockchain as a reward mechanism. This work is partially funded by an EMBO grant (IG-2521) to C.A.
dc.identifier.doi10.1101/gr.207464.116
dc.identifier.issn1088-9051
dc.identifier.urihttp://hdl.handle.net/11693/50140
dc.language.isoEnglish
dc.publisherCold Spring Harbor Laboratory Press
dc.relation.isversionofhttps://doi.org/10.1101/gr.207464.116
dc.relation.projectEMBO: IG-2521
dc.source.titleGenome Researchen_US
dc.titleRealizing the potential of blockchain technologies in genomicsen_US
dc.typeReviewen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Realizing_the_potential_of_blockchain_technologies.pdf
Size:
904.89 KB
Format:
Adobe Portable Document Format
Description:
View / Download
Download

Collections

Scholarly Publications - Computer Engineering