High resolution dielectric characterization of single cells and microparticles using integrated microfluidic microwave sensors

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buir.contributor.authorSeçme, Arda
buir.contributor.authorTefek, Uzay
buir.contributor.authorSarı, Burak
buir.contributor.authorPisheh, Hadi Sedaghat
buir.contributor.authorUslu, H. Dilara
buir.contributor.authorAkbulut, Özge
buir.contributor.authorKüçükoğlu, Berk
buir.contributor.authorŞahin, Özgür
buir.contributor.authorAlhmoud, Hashim
buir.contributor.authorErdogan, R. Tufan
buir.contributor.authorHanay, M. Selim
buir.contributor.orcidTefek, Uzay|0000-0001-6639-0783
buir.contributor.orcidSarı, Burak|0000-0002-8921-9564
buir.contributor.orcidAlhmoud, Hashim|0000-0001-5557-6689
buir.contributor.orcidErdogan, R. Tufan|0000-0001-7657-6362
buir.contributor.orcidHanay, M. Selim|0000-0002-1928-044X
dc.citation.epage13en_US
dc.citation.spage1en_US
dc.contributor.authorSeçme, Arda
dc.contributor.authorTefek, Uzay
dc.contributor.authorSarı, Burak
dc.contributor.authorPisheh, Hadi Sedaghat
dc.contributor.authorUslu, H. Dilara
dc.contributor.authorAkbulut, Özge
dc.contributor.authorKüçükoğlu, Berk
dc.contributor.authorErdogan, R. Tufan
dc.contributor.authorAlhmoud, Hashim
dc.contributor.authorŞahin, Özgür
dc.contributor.authorHanay, M. Selim
dc.date.accessioned2023-03-23T07:57:17Z
dc.date.available2023-03-23T07:57:17Z
dc.date.issued2023-03-01
dc.departmentDepartment of Mechanical Engineeringen_US
dc.description.abstractMicrowave sensors can probe intrinsic material properties of analytes in a microfluidic channel at physiologically relevant ion concentrations. While microwave sensors have been used to detect single cells and microparticles in earlier studies, the synergistic use and comparative analysis of microwave sensors with optical microscopy for material classification and size tracking applications have been scarcely investigated so far. Here we combined microwave and optical sensing to differentiate microscale objects based on their dielectric properties. We designed and fabricated two types of planar sensor: a Coplanar Waveguide Resonator (CPW) and a Split-Ring Resonator (SRR). Both sensors possessed sensing electrodes with a narrow gap to detect single cells passing through a microfluidic channel integrated on the same chip. We also show that standalone microwave sensors can track the relative changes in cellular size in real-time. In sensing single 20-micron diameter polystyrene particles, Signal-to-Noise ratio values of approximately 100 for CPW and 70 for SRR sensors were obtained. These findings demonstrate that microwave sensing technology can serve as a complementary technique for single-cell biophysical experiments and microscale pollutant screening.en_US
dc.identifier.doi10.1109/JSEN.2023.3250401en_US
dc.identifier.eissn1558-1748
dc.identifier.issn1530-437X
dc.identifier.urihttp://hdl.handle.net/11693/112306
dc.language.isoEnglishen_US
dc.publisherInstitute of Electrical and Electronics Engineersen_US
dc.relation.isversionofhttps://doi.org/10.1109/JSEN.2023.3250401en_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.source.titleIEEE Sensors Journalen_US
dc.subjectMicrowave resonatorsen_US
dc.subjectMicrofluidicsen_US
dc.subjectMicroplasticsen_US
dc.subjectMicrofluidic sensorsen_US
dc.subjectOptical microscopyen_US
dc.subjectSplit-Ring resonatorsen_US
dc.subjectCoplanar waveguide resonatorsen_US
dc.subjectMicrowave sensorsen_US
dc.subjectOn-chip sensorsen_US
dc.subjectLabel-free cell detectionen_US
dc.subjectDielectric characterizationen_US
dc.subjectImpedance cytometryen_US
dc.subjectImpedance spectroscopyen_US
dc.subjectDebye screeningen_US
dc.titleHigh resolution dielectric characterization of single cells and microparticles using integrated microfluidic microwave sensorsen_US
dc.typeArticleen_US

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