Resveratrol affects histone 3 lysine 27 methylation of vessels and blood biomarkers in DOCA salt-induced hypertension

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dc.citation.epage42en_US
dc.citation.issueNumber1en_US
dc.citation.spage35en_US
dc.citation.volumeNumber42en_US
dc.contributor.authorHan, S.en_US
dc.contributor.authorUludag, M.O.en_US
dc.contributor.authorUsanmaz, S.E.en_US
dc.contributor.authorAyaloglu-Butun F.en_US
dc.contributor.authorAkcali, K.C.en_US
dc.contributor.authorDemirel-Yilmaz, E.en_US
dc.date.accessioned2016-02-08T10:11:11Z
dc.date.available2016-02-08T10:11:11Z
dc.date.issued2015en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractHypertension is a risk factor for the cardiovascular diseases. Although, several drugs are used to treat hypertension, the success of the antihypertensive therapy is limited. Resveratrol decreases blood pressure in animal models of hypertension. This study researched the mechanisms behind the effects of resveratrol on hypertension. Hypertension was induced by using the deoxycorticosterone acetate (DOCA)-induced (15 mg/kg twice per week, subcutaneously) salt-sensitive hypertension model of Wistar rats. Hypertension caused a decrease in endothelium-dependent relaxations of the isolated thoracic aorta. Resveratrol treatment (50 mg/l in drinking water) prevented DOCA salt-induced hypertension, but did not improve endothelial dysfunction. Plasma nitric oxide (NO), asymmetric dimethylarginine (ADMA), total antioxidant capacity (TAC) and hydrogen sulfide (H2S) levels were not changed by DOCA salt application. However, treatment of resveratrol significantly decreased ADMA and increased TAC and H2S levels. NO level in circulation was not significantly changed by resveratrol. DOCA salt application and resveratrol treatment also caused an alteration in the epigenetic modification of vessels. Staining pattern of histone 3 lysine 27 methylation (H3K27me3) in the aorta and renal artery sections was changed. These results show that preventive effect of resveratrol on DOCA salt-induced hypertension might due to its action on the production of some blood biomarkers and the epigenetic modification of vessels that would focus upon new aspect of hypertension prevention and treatment. © 2014, Springer Science+Business Media Dordrecht.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:11:11Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2015en
dc.identifier.doi10.1007/s11033-014-3737-xen_US
dc.identifier.issn0301-4851
dc.identifier.urihttp://hdl.handle.net/11693/23270
dc.language.isoEnglishen_US
dc.publisherKluwer Academic Publishersen_US
dc.relation.isversionofhttp://dx.doi.org/10.1007/s11033-014-3737-xen_US
dc.source.titleMolecular Biology Reportsen_US
dc.subjectBiomarkeren_US
dc.subjectEndotheliumen_US
dc.subjectEpigenetic modificationen_US
dc.subjectHypertensionen_US
dc.subjectResveratrolen_US
dc.subjecthistone 3 lysine 27en_US
dc.subjecthistone H3en_US
dc.subjecthydrogen sulfideen_US
dc.subjectn(g),n(g) dimethylarginineen_US
dc.subjectnitric oxideen_US
dc.subjectresveratrolen_US
dc.subjectunclassified drugen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectantioxidant activityen_US
dc.subjectArticleen_US
dc.subjectcontrolled studyen_US
dc.subjectdeoxycorticosterone-salt induced hypertensionen_US
dc.subjecthistone methylationen_US
dc.subjectmaleen_US
dc.subjectnonhumanen_US
dc.subjectraten_US
dc.subjectrenal arteryen_US
dc.subjectthoracic aortaen_US
dc.subjectvascular endotheliumen_US
dc.subjectvasodilatationen_US
dc.titleResveratrol affects histone 3 lysine 27 methylation of vessels and blood biomarkers in DOCA salt-induced hypertensionen_US
dc.typeArticleen_US

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