An integrated microfluidic device for the sorting of yeast cells using image processing

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buir.contributor.authorElbüken, Çağlar
dc.citation.epage3550-12en_US
dc.citation.issueNumber1en_US
dc.citation.spage3550-1en_US
dc.citation.volumeNumber8en_US
dc.contributor.authorYu, B. Y.en_US
dc.contributor.authorElbüken, Çağlaren_US
dc.contributor.authorShen, C.en_US
dc.contributor.authorHuissoon, J. P.en_US
dc.contributor.authorRen, C. L.en_US
dc.date.accessioned2019-02-21T16:02:35Z
dc.date.available2019-02-21T16:02:35Z
dc.date.issued2018en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractThe process of detection and separation of yeast cells based on their morphological characteristics is critical to the understanding of cell division cycles, which is of vital importance to the understanding of some diseases such as cancer. The traditional process of manual detection is usually tedious and inconsistent. This paper presents a microfluidic device integrated with microvalves for fluid control for the sorting of yeast cells using image processing algorithms and confirmation based on their fluorescent tag. The proposed device is completely automated, low cost and easy to implement in an academic research setting. Design details of the integrated microfluidic system are highlighted in this paper, along with experimental validation. Real time cell sorting was demonstrated with a cell detection rate of 12 cells per minute.
dc.description.provenanceMade available in DSpace on 2019-02-21T16:02:35Z (GMT). No. of bitstreams: 1 Bilkent-research-paper.pdf: 222869 bytes, checksum: 842af2b9bd649e7f548593affdbafbb3 (MD5) Previous issue date: 2018en
dc.identifier.doi10.1038/s41598-018-21833-9
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11693/50020
dc.language.isoEnglish
dc.publisherNature Publishing Group
dc.relation.isversionofhttps://doi.org/10.1038/s41598-018-21833-9
dc.rightsinfo:eu-repo/semantics/openAccess
dc.source.titleScientific Reportsen_US
dc.subjectBiomedical engineering
dc.subjectImaging and sensing
dc.titleAn integrated microfluidic device for the sorting of yeast cells using image processingen_US
dc.typeArticleen_US

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