Lack of association between the MDM2-SNP309 polymorphism and breast cancer risk

dc.citation.epage4977en_US
dc.citation.issueNumber6 Cen_US
dc.citation.spage4975en_US
dc.citation.volumeNumber26en_US
dc.contributor.authorPetenkaya, A.en_US
dc.contributor.authorBozkurt, B.en_US
dc.contributor.authorAkilli-Ozturk, O.en_US
dc.contributor.authorKaya, H. S.en_US
dc.contributor.authorGur-Dedeoglu, B.en_US
dc.contributor.authorYulug, I. G.en_US
dc.date.accessioned2016-02-08T10:17:22Z
dc.date.available2016-02-08T10:17:22Z
dc.date.issued2006en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractBackground: A T-to-G polymorphism (SNP309) at the promoter region of MDM2 has been recently reported to extend the Sp1 binding site that positively regulates the MDM2 transcription level and consequently, its expression level. MDM2 is the negative regulator of p53 tumor suppressor protein and elevated levels of MDM2 hamper the stress response driven by the p53 pathway. Whether MDM2-SNP309 was associated with breast cancer as a predisposing factor was investigated. Patients and Methods: A case-control study of 223 females diagnosed with breast cancer and 149 female controls sampled from the Turkish population was carried out and the T/G MDM2-SNP309 genotype of participants was determined. Results: There was no significant association of the G/G or G/T genotypes with breast cancer risk (odds ratio (OR) 1.14, 95% confidence interval (CI) 0.59-2.22, and OR 1.20, 95% CI 0.67-2.12, respectively). Stratification of the data for onset age or for menopausal status at the time of diagnosis also revealed no association for either group.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:17:22Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2006en
dc.identifier.issn0250-7005
dc.identifier.urihttp://hdl.handle.net/11693/23675
dc.language.isoEnglishen_US
dc.publisherDelinasios GJ & COen_US
dc.source.titleAnticancer Researchen_US
dc.subjectBreast canceren_US
dc.subjectMDM2 polymorphismen_US
dc.subjectProtein MDM2en_US
dc.subjectageden_US
dc.subjectCancer diagnosisen_US
dc.subjectCancer risken_US
dc.subjectCancer susceptibilityen_US
dc.titleLack of association between the MDM2-SNP309 polymorphism and breast cancer risken_US
dc.typeArticleen_US

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