Towards mechanochemical generation of singlet oxygen

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buir.advisorAkkaya, Engin Umut
dc.contributor.authorAydonat, Simay
dc.date.accessioned2019-01-15T05:46:48Z
dc.date.available2019-01-15T05:46:48Z
dc.date.copyright2018-12
dc.date.issued2018-12
dc.date.submitted2019-01-14
dc.departmentDepartment of Chemistryen_US
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (M.S.): Bilkent University, Department of Chemistry, İhsan Doğramacı Bilkent University, 2018.en_US
dc.descriptionIncludes bibliographical references. (leaves 51-63).en_US
dc.description.abstractSinglet oxygen is a short-lived reactive species which is involved a number of biochemical processes and implicated as the primary photo-generated cytotoxic agent in photodynamic therapy (PDT) of cancer. Precise chemical control of singlet oxygen generation and or storage is therefore of immense interest. In this particular study, the possibility of mechanochemical release of singlet oxygen in cross-linked polymers carrying anthracene 9,10-endoperoxides was explored. 9,10-Diphenylanthracenes are stable at room temperature but undergo thermal cycloreversion when heated to produce singlet oxygen. Thus, a cross-linked polyacrylate was synthesized, incorporating anthracene-endoperoxide modules with chain extensions at the 9,10-positions. Previously in our lab, thermal lability of the anthracene endoperoxides were shown when attached to gold nanorods. In this work, it was demonstrated that on mechanical agitation in a cryogenic ball mill, fluorescence emission due to anthracene units in the polymer is enhanced, with a concomitant generation of singlet oxygen as proved by detection with a selective probe, SOSG. Also, a cross-linked polyacrylate and a PDMS elastomer incorporating anthracene-endoperoxide modules with chain extensions at the 9,10-positions were synthesized as the polymeric matrix for a better manifestation of mechanochemical process.en_US
dc.description.degreeM.S.en_US
dc.description.provenanceSubmitted by Betül Özen (ozen@bilkent.edu.tr) on 2019-01-15T05:46:48Z No. of bitstreams: 1 Simay Aydonat-Master Thesis.pdf: 2054817 bytes, checksum: 7bf90a23e9d1374e173ef956dc9e12bc (MD5)en
dc.description.provenanceMade available in DSpace on 2019-01-15T05:46:48Z (GMT). No. of bitstreams: 1 Simay Aydonat-Master Thesis.pdf: 2054817 bytes, checksum: 7bf90a23e9d1374e173ef956dc9e12bc (MD5) Previous issue date: 2019-01en
dc.description.statementofresponsibilityby Simay Aydonat.en_US
dc.embargo.release2019-07-14
dc.format.extentxviii, 73 leaves : illustrations, charts (some color) ; 30 cm.en_US
dc.identifier.itemidB159519
dc.identifier.urihttp://hdl.handle.net/11693/48245
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPhotodynamic Therapyen_US
dc.subjectSinglet Oxygenen_US
dc.subjectEndoperoxideen_US
dc.subjectMechanochemistryen_US
dc.subjectPolymerizationen_US
dc.titleTowards mechanochemical generation of singlet oxygenen_US
dc.title.alternativeMekanokimyasal yöntemlerle singlet oksijen üretimien_US
dc.typeThesisen_US

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