Working memory in unaffected relatives of patients with schizophrenia: a meta-analysis of functional magnetic resonance imaging studies

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dc.citation.epage1077en_US
dc.citation.issueNumber4en_US
dc.citation.spage1068en_US
dc.citation.volumeNumber42en_US
dc.contributor.authorZhang, R.en_US
dc.contributor.authorPicchioni, M.en_US
dc.contributor.authorAllen, P.en_US
dc.contributor.authorToulopoulou, T.en_US
dc.date.accessioned2018-04-12T10:44:22Z
dc.date.available2018-04-12T10:44:22Z
dc.date.issued2016en_US
dc.departmentDepartment of Psychologyen_US
dc.description.abstractWorking memory deficits, a core cognitive feature of schizophrenia may arise from dysfunction in the frontal and parietal cortices. Numerous studies have also found abnormal neural activation during working memory tasks in patients' unaffected relatives. The aim of this study was to systematically identify and anatomically localize the evidence for those activation differences across all eligible studies. Fifteen functional magnetic resonance imaging (fMRI) manuscripts, containing 16 samples of 289 unaffected relatives of patients with schizophrenia, and 358 healthy controls were identified that met our inclusion criteria: (1) used a working memory task; and (2) reported standard space coordinates. Activation likelihood estimation (ALE) identified convergence across studies. Compared to healthy controls, patients' unaffected relatives showed decreases in neural activation in the right middle frontal gyrus (BA9), as well as right inferior frontal gyrus (BA44). Increased activation was seen in relatives in the right frontopolar (BA10), left inferior parietal lobe (BA40), and thalamus bilaterally. These results suggest that the familial risk of schizophrenia is expressed in changes in neural activation in the unaffected relatives in the cortical-subcortical working memory network that includes, but is not restricted to the middle prefrontal cortex.en_US
dc.description.provenanceMade available in DSpace on 2018-04-12T10:44:22Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2016en
dc.identifier.doi10.1093/schbul/sbv221en_US
dc.identifier.eissn1745-1701
dc.identifier.issn0586-7614
dc.identifier.urihttp://hdl.handle.net/11693/36563en_US
dc.publisherOxford University Pressen_US
dc.relation.isversionofhttp://dx.doi.org/10.1093/schbul/sbv221en_US
dc.source.titleSchizophrenia Bulletinen_US
dc.subjectDorsolateral prefrontal cortexen_US
dc.subjectEndophenotypeen_US
dc.subjectFunctional magnetic resonance imaging (fMRI)en_US
dc.subjectIntermediate phenotypeen_US
dc.subjectMeta-analysesen_US
dc.subjectMeasurementen_US
dc.subjectMeta analysisen_US
dc.titleWorking memory in unaffected relatives of patients with schizophrenia: a meta-analysis of functional magnetic resonance imaging studiesen_US
dc.typeArticleen_US

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