Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion

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buir.contributor.authorUçar, Esma
buir.contributor.orcidUçar, Esma|0000-0001-8639-9777
dc.citation.epage14516en_US
dc.citation.issueNumber24en_US
dc.citation.spage14513en_US
dc.citation.volumeNumber11en_US
dc.contributor.authorLiu, M.
dc.contributor.authorUçar, Esma
dc.contributor.authorLiu, Z.
dc.contributor.authorWang, L.
dc.contributor.authorYang, L.
dc.contributor.authorXu, J.
dc.contributor.authorAkkaya, E. U.
dc.date.accessioned2022-02-10T13:37:59Z
dc.date.available2022-02-10T13:37:59Z
dc.date.issued2021-04-19
dc.departmentDepartment of Chemistryen_US
dc.description.abstractSinglet oxygen generated by photosensitization has limited potential in vivo due to light attenuation in tissues. However, controlled chemical generation of this reactive oxygen species is likely to open new therapeutic spaces to explore. The fact that its activity is limited by the rate of cycloreversion reaction and the diffusion distance of the excited state molecular oxygen species, is a clear advantage, considering the serious side effects of off-target anticoagulants. In this work, we present novel 1,4-naphthalene endoperoxides as potential anti-coagulant agents due to thermal release of singlet oxygen.en_US
dc.description.provenanceSubmitted by Mustafa Er (mer@bilkent.edu.tr) on 2022-02-10T13:37:59Z No. of bitstreams: 1 Anticoagulant_activity_of_singlet_oxygen_released_from_a_water_soluble_endoperoxide_by_thermal_cycloreversion.pdf: 444825 bytes, checksum: 3f06b51062b81ae1b887501359ad978f (MD5)en
dc.description.provenanceMade available in DSpace on 2022-02-10T13:37:59Z (GMT). No. of bitstreams: 1 Anticoagulant_activity_of_singlet_oxygen_released_from_a_water_soluble_endoperoxide_by_thermal_cycloreversion.pdf: 444825 bytes, checksum: 3f06b51062b81ae1b887501359ad978f (MD5) Previous issue date: 2021-04-19en
dc.identifier.doi10.1039/d1ra02569den_US
dc.identifier.eissn2046-2069
dc.identifier.urihttp://hdl.handle.net/11693/77252
dc.language.isoEnglishen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isversionofhttps://doi.org/10.1039/d1ra02569den_US
dc.source.titleRSC Advancesen_US
dc.titleAnticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversionen_US
dc.typeArticleen_US

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