Great ape genetic diversity and population history

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dc.citation.epage1en_US
dc.citation.issueNumber7459en_US
dc.citation.spage12en_US
dc.citation.volumeNumber499en_US
dc.contributor.authorPrado-Martinez, J.en_US
dc.contributor.authorEichler, E. E.en_US
dc.contributor.authorMarques-Bonet, T.en_US
dc.contributor.authorSudmant, P. H.en_US
dc.contributor.authorKidd, J. M.en_US
dc.contributor.authorLi, H.en_US
dc.contributor.authorKelley, J. L.en_US
dc.contributor.authorLorente-Galdos, B.en_US
dc.contributor.authorVeeramah, K. R.en_US
dc.contributor.authorWoerner, A. E.en_US
dc.contributor.authorO’Connor, T. D.en_US
dc.contributor.authorSantpere, G.en_US
dc.contributor.authorCagan, A.en_US
dc.contributor.authorTheunert, C.en_US
dc.contributor.authorCasals, F.en_US
dc.contributor.authorLaayouni, H.en_US
dc.contributor.authorMunch, K.en_US
dc.contributor.authorHobolth, A.en_US
dc.contributor.authorHalager, A. E.en_US
dc.contributor.authorMalig, M.en_US
dc.contributor.authorHernandez-Rodriguez, J.en_US
dc.contributor.authorHernando-Herraez, I.en_US
dc.contributor.authorPrüfer, K.en_US
dc.contributor.authorPybus, M.en_US
dc.contributor.authorJohnstone, L.en_US
dc.contributor.authorLachmann, M.en_US
dc.contributor.authorAlkan C.en_US
dc.contributor.authorTwig, D.en_US
dc.contributor.authorPetit, N.en_US
dc.contributor.authorBaker, C.en_US
dc.contributor.authorHormozdiari, F.en_US
dc.contributor.authorFernandez-Callejo, M.en_US
dc.contributor.authorDabad, M.en_US
dc.contributor.authorWilson, M. L.en_US
dc.contributor.authorStevison, L.en_US
dc.contributor.authorCamprubí, C.en_US
dc.contributor.authorCarvalho, T.en_US
dc.contributor.authorRuizHerrera, A.en_US
dc.contributor.authorVives, L.en_US
dc.contributor.authorMele, M.en_US
dc.contributor.authorAbello, T.en_US
dc.contributor.authorKondova, I.en_US
dc.contributor.authorBontrop, R. E.en_US
dc.contributor.authorPusey, A.en_US
dc.contributor.authorLankester, F.en_US
dc.contributor.authorKiyang, J. A.en_US
dc.contributor.authorBergl, R. A.en_US
dc.contributor.authorLonsdorf, E.en_US
dc.contributor.authorMyers, S.en_US
dc.contributor.authorVentura, M.en_US
dc.contributor.authorGagneux, P.en_US
dc.contributor.authorComas, D.en_US
dc.contributor.authorSiegismund, H.en_US
dc.contributor.authorBlanc, J.en_US
dc.contributor.authorAgueda-Calpena, L.en_US
dc.contributor.authorGut, M.en_US
dc.contributor.authorFulton, L.en_US
dc.contributor.authorTishkoff, S. A.en_US
dc.contributor.authorMullikin, J. C.en_US
dc.contributor.authorWilson, R. K.en_US
dc.contributor.authorGut, I. G.en_US
dc.contributor.authorGonder, M K.en_US
dc.contributor.authorRyder, O. A.en_US
dc.contributor.authorHahn, B. H.en_US
dc.contributor.authorNavarro, A.en_US
dc.contributor.authorAkey, J. M.en_US
dc.contributor.authorBertranpetit, J.en_US
dc.contributor.authorReich, D.en_US
dc.contributor.authorMailund, T.en_US
dc.contributor.authorSchierup, M. H.en_US
dc.contributor.authorHvilsom, C.en_US
dc.contributor.authorAndrés, A. M.en_US
dc.contributor.authorWall, J. D.en_US
dc.contributor.authorBustamante, C. D.en_US
dc.contributor.authorHammer, M. F.en_US
dc.date.accessioned2015-07-28T12:04:09Z
dc.date.available2015-07-28T12:04:09Z
dc.date.issued2013en_US
dc.departmentDepartment of Computer Engineeringen_US
dc.description.abstractMost great ape genetic variation remains uncharacterized(1,2); however, its study is critical for understanding population history(3-6), recombination(7), selection(8) and susceptibility to disease(9,10). Here we sequence to high coverage a total of 79 wild-and captive-born individuals representing all six great ape species and seven subspecies and report 88.8 million single nucleotide polymorphisms. Our analysis provides support for genetically distinct populations within each species, signals of gene flow, and the split of common chimpanzees into two distinct groups: Nigeria-Cameroon/western and central/eastern populations. We find extensive inbreeding in almost all wild populations, with eastern gorillas being the most extreme. Inferred effective population sizes have varied radically over time in different lineages and this appears to have a profound effect on the genetic diversity at, or close to, genes in almost all species. We discover and assign 1,982 loss-of-function variants throughout the human and great ape lineages, determining that the rate of gene loss has not been different in the human branch compared to other internal branches in the great ape phylogeny. This comprehensive catalogue of great ape genome diversity provides a framework for understanding evolution and a resource for more effective management of wild and captive great ape populations.en_US
dc.identifier.doi10.1038/nature12228en_US
dc.identifier.eissn1476-4687
dc.identifier.issn0028-0836
dc.identifier.urihttp://hdl.handle.net/11693/12976
dc.language.isoEnglishen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/nature12228en_US
dc.source.titleNature: international weekly journal of scienceen_US
dc.subjectHuman Genomeen_US
dc.subjectChimpanzee Genomeen_US
dc.subjectSequenceen_US
dc.subjectEvolutionen_US
dc.subjectSelectionen_US
dc.subjectPatternsen_US
dc.subjectDeclineen_US
dc.titleGreat ape genetic diversity and population historyen_US
dc.typeArticleen_US

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