Nanostructured materials for biological imaging and chemical sensing

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buir.advisorBayındır, Mehmet
dc.contributor.authorYıldırım, Adem
dc.date.accessioned2015-10-22T13:17:10Z
dc.date.available2015-10-22T13:17:10Z
dc.date.copyright2014-11
dc.date.issued2014-11
dc.departmentGraduate Program in Materials Science and Nanotechnologyen_US
dc.descriptionCataloged from PDF version of thesis.en_US
dc.descriptionIncludes bibliographical references (leaves 116-139).en_US
dc.descriptionThesis (Ph. D.): Bilkent University, Materials Science and Nanotechnology Program, İhsan Doğramacı Bilkent University, 2014.en_US
dc.description.abstractIn the recent years, the design and synthesis of fluorescent nanoparticles for biological and chemical sensing applications have received considerable attention due to the excellent photostability and emission intensity of fluorescent nanoparticles and the intrinsic sensitivity of fluorescence based methods. Although considerable progress has been made in their synthesis, there is still need for low-cost and high throughput methods for their widespread utilization in biological and chemical sensing applications. In addition, studies regarding their biocompatibility are necessary to identify the toxicological potential of these nanomaterials. In this context, this thesis seeks new methods for multifunctional fluorescent nanoparticle synthesis and investigates their interactions with living organisms. In addition, it reports the applications of the fluorescent nanomaterials in biological imaging, therapy and chemical sensing applications. First, we report a self-assembly method to prepare PEGylated or peptide functionalized mesoporous silica nanoparticles (MSNs) for cell labeling and drug delivery applications. The good cyto- and blood- compatibility of the functionalized nanoparticles were demonstrated. Next, we demonstrated a surfactant assisted method to synthesize ultrabright silica nanoparticles and studied their in vitro v cytocompatibility with several cell lines. We demonstrated the applications of ultrabright particles in cell labeling, chemo and photodynamic therapy and trace explosive sensing. Then, we discuss a template-free method (porosity difference based selective dissolution strategy) to prepare self-luminescent mesoporous hollow silica nanoparticles with tailored shapes. In addition, we studied the surface effects on blood compatibility of nanoparticles in detail using the MSNs possessing different surface functional groups (ionic, polar, neutral, and hydrophobic). Finally, we investigated the optical properties of polydopamine nanoparticles and showed that fluorescence of asprepared polydopamine nanoparticles can be used for sensitive and selective detection of the dopamine neurotransmitter.en_US
dc.description.degreePh.D.en_US
dc.description.statementofresponsibilityby Adem Yıldırım.en_US
dc.format.extentxxi, 139 leaves : illustrations, charts.en_US
dc.identifier.itemidB149140
dc.identifier.urihttp://hdl.handle.net/11693/14024
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFluorescent nanoparticlesen_US
dc.subjectMesoporous silicaen_US
dc.subjectPolydopamineen_US
dc.subjectBlood compatibilityen_US
dc.subjectCytotoxicityen_US
dc.subjectFluorescent imagingen_US
dc.subjectChemotherapyen_US
dc.subjectPhotodynamic therapyen_US
dc.subjectExplosive sensingen_US
dc.subjectNeurotransmitter sensingen_US
dc.subject.lccTA418.9.N35 Y55 2014en_US
dc.subject.lcshNanostructured materials -- Health aspects -- Research.en_US
dc.subject.lcshNanoparticles.en_US
dc.subject.lcshFluorescent probes.en_US
dc.subject.lcshSilica -- Surfaces.en_US
dc.titleNanostructured materials for biological imaging and chemical sensingen_US
dc.title.alternativeBiyolojik görüntüleme ve kimyasal sensör uygulamalari için nanoyapili malzemelerin geliştirilmesien_US
dc.typeThesisen_US

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Graduate Program in Materials Science and Nanotechnology - Ph.D. / Sc.D.