Synthesis of some substituted 6-phenyl purine analogues and their biological evaluation as cytotoxic agents

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dc.citation.epage632en_US
dc.citation.issueNumber3en_US
dc.citation.spage621en_US
dc.citation.volumeNumber64en_US
dc.contributor.authorKucukdumlu, A.en_US
dc.contributor.authorTuncbilek, M.en_US
dc.contributor.authorGuven, E. B.en_US
dc.contributor.authorAtalay, R. C.en_US
dc.date.accessioned2018-04-12T10:59:51Z
dc.date.available2018-04-12T10:59:51Z
dc.date.issued2017en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractA series of 6-(4-substituted phenyl)-9-(tetrahydropyran-2-yl)purines 3–9, 6-(4-substituted phenyl)purines 10–16, 9-((4-substituted phenyl)sulfonyl)-6-(4-substituted phenyl)purines 17–32 were prepared and screened initially for their in vitro anticancer activity against selected human cancer cells (liver Huh7, colon HCT116, breast MCF7). 6-(4-Phenoxy-phenyl)purine analogues 9, 16, 30–32, had potent cytotoxic activities. The most active purine derivatives 5–9, 14, 16, 18, 28–32 were further screened for their cytotoxic activity in hepatocellular cancer cells. 6-(4-Phenoxyphenyl)-9-(tetrahydropyran-2-yl)-9H-purine (9) had better cytotoxic activity (IC50 5.4 μM) than the well-known nucleobase analogue 5-FU and known nucleoside drug fludarabine on Huh7 cells. The structure–activity relationship studies reported that the substitution at C-6 positions in purine nucleus with the 4-phenoxyphenyl group is responsible for the anti-cancer activity.en_US
dc.identifier.doi10.17344/acsi.2017.3419en_US
dc.identifier.issn1318-0207
dc.identifier.urihttp://hdl.handle.net/11693/37007
dc.language.isoEnglishen_US
dc.publisherSlovensko Kemijsko Drustvoen_US
dc.relation.isversionofhttp://dx.doi.org/10.17344/acsi.2017.3419en_US
dc.source.titleActa Chimica Slovenicaen_US
dc.subjectAntitumor agentsen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectHeterocyclesen_US
dc.subjectPurine derivativesen_US
dc.subjectStructure-activity relationshipsen_US
dc.titleSynthesis of some substituted 6-phenyl purine analogues and their biological evaluation as cytotoxic agentsen_US
dc.typeArticleen_US

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