Novel near-ir photosensitizers for photodynamic therapy and designing heavy atom free photosensitizers for the photodynamic therapy

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buir.advisorAkkaya, Engin U.
dc.contributor.authorKılıç, Bilal
dc.date.accessioned2016-04-27T06:34:19Z
dc.date.available2016-04-27T06:34:19Z
dc.date.copyright2016-03
dc.date.issued2016-03
dc.date.submitted08-03-2016
dc.departmentGraduate Program in Materials Science and Nanotechnologyen_US
dc.descriptionCataloged from PDF version of thesis.en_US
dc.descriptionIncludes bibliographical references (leaves 136-148).en_US
dc.descriptionThesis (Ph. D.): Bilkent University, Materials Science and Nanotechnology Program, İhsan Doğramacı Bilkent University, 2016.en_US
dc.description.abstractPhotodynamic therapy (PDT) is a promising and emerging noninvasive treatment modality for the treatment of a great number of malignant and non-malignant diseases. Therapeutic strategy in PDT is performed by combining a photosensitizer which can potently and specifically kill diseased cell and a light source, preferentially near-IR light (650-800 nm). In spite of the fact that numerous studies have been published and notable progress has been made in tumor biology and photochemistry which let us to design novel therapeutic agents, the number of the new therapeutic agents which have been recently got approval for clinical application are relatively low. We aimed to produce novel photosensitizers. In the chapters 3, 4 and 5 BODIPY dyes which are amenable to functionalization have been used to produce a novel series of BODIPY-based photosensitizers. We synthesized and characterized a series of novel BODIPY-based photosensitizers. The first part describes novel near-IR BODIPY-based photosensitizers. In the second part, the main goal was to design and synthesize heavy atom free BODIPY-based photosensitizers. In this respect, a new modification of the BODIPY dyes, novel orthogonal BODIPYs were synthesized and their computational analysis were done. A cell culture assay with cancer cell lines was performed in order to demonstrate photocytotoxicity of the orthogonal BODIPY. The third study underlines the importance of micelle-embedded BODIPY-based photosensitizers for photodynamic therapy.en_US
dc.description.degreePh.D.en_US
dc.description.provenanceSubmitted by Betül Özen (ozen@bilkent.edu.tr) on 2016-04-27T06:34:19Z No. of bitstreams: 1 Bilal Kilic PhD Thesis .pdf: 7473835 bytes, checksum: 1ee2d8fef0f9a8f75e37abe8e52d1ae0 (MD5)en
dc.description.provenanceMade available in DSpace on 2016-04-27T06:34:19Z (GMT). No. of bitstreams: 1 Bilal Kilic PhD Thesis .pdf: 7473835 bytes, checksum: 1ee2d8fef0f9a8f75e37abe8e52d1ae0 (MD5) Previous issue date: 2016-03en
dc.description.statementofresponsibilityby Bilal Kılıçen_US
dc.embargo.release2017-03-05
dc.format.extentxviii, 196 leaves : illustrations, charts.en_US
dc.identifier.itemidB152897
dc.identifier.urihttp://hdl.handle.net/11693/28991
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPhotodynamic therapyen_US
dc.subjectSinglet oxygenen_US
dc.subjectBoradiazaindaceneen_US
dc.titleNovel near-ir photosensitizers for photodynamic therapy and designing heavy atom free photosensitizers for the photodynamic therapyen_US
dc.title.alternativeFotodinamik terapi için kızıl ötesi ışığı soğurabilen yeni fotoduyarlaştırıcı ve ağır atom içermeyen fotoduyarlaştırıcıların tasarlanmasıen_US
dc.typeThesisen_US

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Graduate Program in Materials Science and Nanotechnology - Ph.D. / Sc.D.