Assessment of the corticospinal fiber integrity in mirror movement disorder

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dc.citation.epage76en_US
dc.citation.spage69en_US
dc.citation.volumeNumber54en_US
dc.contributor.authorSolmaz, B.en_US
dc.contributor.authorÖzyurt, M. G.en_US
dc.contributor.authorAta, D. B.en_US
dc.contributor.authorAkçimen, F.en_US
dc.contributor.authorShabsog, M.en_US
dc.contributor.authorTürker, K. S.en_US
dc.contributor.authorDalçik, H.en_US
dc.contributor.authorAlgin, O.en_US
dc.contributor.authorBaşak, A. N.en_US
dc.contributor.authorÖzgür, M.en_US
dc.contributor.authorÇavdar, S.en_US
dc.date.accessioned2019-02-21T16:01:46Z
dc.date.available2019-02-21T16:01:46Z
dc.date.issued2018en_US
dc.departmentNational Magnetic Resonance Research Center (UMRAM)en_US
dc.description.abstractMirror movements are unintended movements occurring on one side of the body that mirror the contralateral voluntary ones. It has been proposed that mirror movements occur due to abnormal decussation of the corticospinal pathways. Using detailed multidisciplinary approach, we aimed to enlighten the detailed mechanism underlying the mirror movements in a case subject who is diagnosed with mirror movements of the hands and we compared the findings with the unaffected control subjects. To evaluate the characteristics of mirror movements, we used several techniques including whole exome sequencing, computed tomography, diffusion tensor imaging and transcranial magnetic stimulation. Computed tomography showed the absence of a spinous process of C5, fusion of the body of C5-C6 vertebrae, hypoplastic dens and platybasia of the posterior cranial fossa. A syrinx cavity was present between levels C3-C4 of the spinal cord. Diffusion tensor imaging of the corticospinal fibers showed disorganization and minimal decussations at the lower medulla oblongata. Transcranial magnetic stimulation showed that motor commands were distributed to the motor neuron pools on the left and right sides of the spinal cord via fast-conducting corticospinal tract fibers. Moreover, a heterozygous missense variation in the deleted in colorectal carcinoma gene has been observed. Developmental absence of the axonal guidance molecules or their receptors may result in abnormalities in the leading of the corticospinal fibers. Clinical evaluations and basic neuroscience techniques, in this case, provide information for this rare disease and contribute to our understanding of the normal physiology of bimanual coordination.
dc.description.sponsorshipWe would like to thank our index patient and control subjects for their participation. Also, we acknowledge the role of Koç University, Bilkent University as well as Suna and İnan Kıraç Foundation for funding this study.
dc.identifier.doi10.1016/j.jocn.2018.06.001
dc.identifier.issn0967-5868
dc.identifier.urihttp://hdl.handle.net/11693/49914
dc.language.isoEnglish
dc.publisherChurchill Livingstone
dc.relation.isversionofhttps://doi.org/10.1016/j.jocn.2018.06.001
dc.relation.projectBilkent Üniversitesi
dc.source.titleJournal of Clinical Neuroscienceen_US
dc.subjectCorticospinal tractsen_US
dc.subjectElectrophysiologyen_US
dc.subjectMirror movementsen_US
dc.subjectNeural tube defecten_US
dc.titleAssessment of the corticospinal fiber integrity in mirror movement disorderen_US
dc.typeArticleen_US

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