The association of cognitive impairment with gray matter atrophy and cortical lesion load in clinically isolated syndrome

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dc.citation.epage21en_US
dc.citation.spage14en_US
dc.citation.volumeNumber10en_US
dc.contributor.authorDiker, S.en_US
dc.contributor.authorHas, A. C.en_US
dc.contributor.authorKurne, A.en_US
dc.contributor.authorGöçmen, R.en_US
dc.contributor.authorOğuz, K. K.en_US
dc.contributor.authorKarabudak, R.en_US
dc.date.accessioned2018-04-12T10:53:59Z
dc.date.available2018-04-12T10:53:59Z
dc.date.issued2016en_US
dc.departmentNational Magnetic Resonance Research Center (UMRAM)en_US
dc.description.abstractBackground Multiple sclerosis can impair cognition from the early stages and has been shown to be associated with gray matter damage in addition to white matter pathology. Objectives To investigate the profile of cognitive impairment in clinically isolated syndrome (CIS), and the contribution of cortical inflammation, cortical and deep gray matter atrophy, and white matter lesions to cognitive decline. Methods Thirty patients with clinically isolated syndrome and twenty demographically- matched healthy controls underwent neuropsychologic assessment through the Rao Brief Repeatable Battery, and brain magnetic resonance imaging with double inversion recovery using a 3T scanner. Results Patients with clinically isolated syndrome performed significantly worse than healthy controls on tests that evaluated verbal memory, visuospatial learning and memory, and verbal fluency. Significant deep gray matter atrophy was found in the patients but cortical volume was not lower than the controls. Visual memory tests correlated with the volume of the hippocampus, cerebral white matter and deep gray matter structures and with cerebellar cortical atrophy. Cortical or white matter lesion load did not affect cognitive test results. Conclusion In our patients with CIS, it was shown that cognitive impairment was mainly related to cerebral white matter, cerebellar cortical and deep gray matter atrophy, but not with cortical inflammation, at least in the early stage of disease. © 2016 Elsevier B.V.en_US
dc.description.provenanceMade available in DSpace on 2018-04-12T10:53:59Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2016en
dc.identifier.doi10.1016/j.msard.2016.08.008en_US
dc.identifier.issn2211-0348
dc.identifier.urihttp://hdl.handle.net/11693/36805
dc.language.isoEnglishen_US
dc.publisherElsevier B.V.en_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.msard.2016.08.008en_US
dc.source.titleMultiple Sclerosis and Related Disordersen_US
dc.subjectClinically isolated syndromeen_US
dc.subjectCognitive functionsen_US
dc.subjectCortical lesionen_US
dc.subjectGray matteren_US
dc.subjectMultiple sclerosisen_US
dc.titleThe association of cognitive impairment with gray matter atrophy and cortical lesion load in clinically isolated syndromeen_US
dc.typeArticleen_US

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