IKKs and tumor cell plasticity

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buir.contributor.authorGöktuna, Serkan İsmail
dc.citation.epage2181en_US
dc.citation.issueNumber12en_US
dc.citation.spage2161en_US
dc.citation.volumeNumber285en_US
dc.contributor.authorGöktuna, Serkan İsmailen_US
dc.contributor.authorDiamanti, M. A.en_US
dc.contributor.authorChau, T. L.en_US
dc.date.accessioned2019-02-21T16:06:11Zen_US
dc.date.available2019-02-21T16:06:11Zen_US
dc.date.issued2018en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractNuclear factor κB (NF-κB) transcription factors are the central hubs of signaling pathways connecting proinflammatory signals to cell survival, proliferation and cytokine production. In cancers, NF-κB signaling influences many aspects of tumor development, from initiation to metastasis. These functions are mediated by tumor-induced plasticity that allows tumor cells to adapt and survive in changing conditions within the tumor microenvironment. Tumor cell plasticity is shaped by the inflammatory microenvironment in tumors. This review focuses on inhibitor of NF-κB kinases, the direct upstream elements of NF-κB regulation, specifically on their conventional and non-conventional functions in animal models of tumorigenesis from the recent literature.en_US
dc.embargo.release2019-06-18en_US
dc.identifier.doi10.1111/febs.14444en_US
dc.identifier.eissn1742-4658en_US
dc.identifier.issn1742-464Xen_US
dc.identifier.urihttp://hdl.handle.net/11693/50296en_US
dc.language.isoEnglishen_US
dc.publisherWiley-Blackwell Publishing Ltd.en_US
dc.relation.isversionofhttps://doi.org/10.1111/febs.14444en_US
dc.source.titleThe FEBS Journalen_US
dc.subjectEMTen_US
dc.subjectIkappaB kinasesen_US
dc.subjectIKKen_US
dc.subjectInflammationen_US
dc.subjectMetastasisen_US
dc.subjectStemnessen_US
dc.subjectTumor cell plasticityen_US
dc.titleIKKs and tumor cell plasticityen_US
dc.typeReviewen_US

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Department of Molecular Biology and Genetics
Nanotechnology Research Center (NANOTAM)