Test-retest reliability of myelin imaging in the human spinal cord: Measurement errors versus region-and aging-induced variations

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buir.contributor.authorKhatibi, Ali
dc.citation.issueNumber1en_US
dc.citation.volumeNumber13en_US
dc.contributor.authorLévy, S.en_US
dc.contributor.authorGuertin, M. -C.en_US
dc.contributor.authorKhatibi, Alien_US
dc.contributor.authorMezer, A.en_US
dc.contributor.authorMartinu, K.en_US
dc.contributor.authorChen, J. -I.en_US
dc.contributor.authorStikov, N.en_US
dc.contributor.authorRainville, P.en_US
dc.contributor.authorCohen-Adad, J.en_US
dc.date.accessioned2019-02-21T16:08:05Z
dc.date.available2019-02-21T16:08:05Z
dc.date.issued2018en_US
dc.departmentDepartment of Psychologyen_US
dc.departmentInterdisciplinary Program in Neuroscience (NEUROSCIENCE)en_US
dc.departmentNational Magnetic Resonance Research Center (UMRAM)en_US
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.description.abstractPurpose To implement a statistical framework for assessing the precision of several quantitative MRI metrics sensitive to myelin in the human spinal cord: T1, Magnetization Transfer Ratio (MTR), saturation imposed by an off-resonance pulse (MTsat) and Macromolecular Tissue Volume (MTV). Methods Thirty-three healthy subjects within two age groups (young, elderly) were scanned at 3T. Among them, 16 underwent the protocol twice to assess repeatability. Statistical reliability indexes such as the Minimal Detectable Change (MDC) were compared across metrics quantified within different cervical levels and white matter (WM) sub-regions. The differences between pathways and age groups were quantified and interpreted in context of the test-retest repeatability of the measurements. Results The MDC was respectively 105.7ms, 2.77%, 0.37% and 4.08% for T1, MTR, MTsat and MTV when quantified over all WM, while the standard-deviation across subjects was 70.5ms, 1.34%, 0.20% and 2.44%. Even though particular WM regions did exhibit significant differences, these differences were on the same order as test-retest errors. No significant difference was found between age groups for all metrics. Conclusion While T1-based metrics (T1 and MTV) exhibited better reliability than MT-based measurements (MTR and MTsat), the observed differences between subjects or WM regions were comparable to (and often smaller than) the MDC. This makes it difficult to determine if observed changes are due to variations in myelin content, or simply due to measurement error. Measurement error remains a challenge in spinal cord myelin imaging, but this study provides statistical guidelines to standardize the field and make it possible to conduct large-scale multi-center studies.
dc.description.provenanceMade available in DSpace on 2019-02-21T16:08:05Z (GMT). No. of bitstreams: 1 Bilkent-research-paper.pdf: 222869 bytes, checksum: 842af2b9bd649e7f548593affdbafbb3 (MD5) Previous issue date: 2018en
dc.identifier.doi10.1371/journal.pone.0189944
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11693/50397
dc.language.isoEnglish
dc.publisherPublic Library of Science
dc.relation.isversionofhttps://doi.org/10.1371/journal.pone.0189944
dc.rightsinfo:eu-repo/semantics/openAccess
dc.source.titlePLoS ONEen_US
dc.titleTest-retest reliability of myelin imaging in the human spinal cord: Measurement errors versus region-and aging-induced variationsen_US
dc.typeArticleen_US

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