Germ line BRCA1 and BRCA2 gene mutations in Turkish breast cancer patients

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dc.citation.epage2082en_US
dc.citation.issueNumber16en_US
dc.citation.spage2076en_US
dc.citation.volumeNumber36en_US
dc.contributor.authorÖzdag, H.en_US
dc.contributor.authorTez, M.en_US
dc.contributor.authorSayek, I.en_US
dc.contributor.authorMüslümanoglu, M.en_US
dc.contributor.authorTarcan, O.en_US
dc.contributor.authorIçli, F.en_US
dc.contributor.authorÖztürk, M.en_US
dc.contributor.authorÖzçelik, T.en_US
dc.date.accessioned2015-07-28T11:56:59Z
dc.date.available2015-07-28T11:56:59Z
dc.date.issued2000-10en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractGerm line BRCA1 and/or BRCA2 mutations were screened in 50 Turkish breast and/or ovarian cancer patients composed of hereditary, familial, early onset and male cancer groups. Genomic DNA samples were tested by heteroduplex analysis and DNA sequencing. Two truncating BRCA2 mutations, one novel (6880 insG) and one previously reported (3034 delAAAC), were found in two out of six (33%) hereditary breast and/or ovarian cancer patients. A novel truncating (1200 insA) and a missense (2080A→G) BRCA1 mutation was found in two of 27 (7%) individuals in the early onset group. A total of four (8%) disease-causing mutations in 50 breast cancer patients were identified in BRCA1 and BRCA2 genes. In addition, five BRCA1 sequence variants have been identified in 23 patients. These results indicate that BRCA1 and BRCA2 genes are involved in some, but not all, forms of hereditary predisposition to breast cancer in the Turkish population.en_US
dc.identifier.doi10.1016/S0959-8049(00)00277-Xen_US
dc.identifier.issn0959-8049
dc.identifier.urihttp://hdl.handle.net/11693/11152
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/S0959-8049(00)00277-Xen_US
dc.source.titleEuropean Journal of Canceren_US
dc.subjectBrca1en_US
dc.subjectBrca2en_US
dc.subjectGerm line mutationen_US
dc.subjectHereditary breast/ovarian canceren_US
dc.titleGerm line BRCA1 and BRCA2 gene mutations in Turkish breast cancer patientsen_US
dc.typeArticleen_US

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