Formulation of a fast-disintegrating drug delivery system from cyclodextrin/naproxen inclusion complex nanofibrous films

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buir.contributor.authorDurgun, Engin
buir.contributor.orcidDurgun, Engin|0000-0002-0639-5862
dc.citation.epage606en_US
dc.citation.issueNumber2
dc.citation.spage595
dc.citation.volumeNumber15
dc.contributor.authorCelebioglu, Asli
dc.contributor.authorDash, Kareena
dc.contributor.authorAboelkheir, Mahmoud
dc.contributor.authorKilic, Mehmet E.
dc.contributor.authorDurgun, Engin
dc.contributor.authorUyar, Tamer
dc.date.accessioned2024-03-22T12:46:50Z
dc.date.available2024-03-22T12:46:50Z
dc.date.issued2023-12-21
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)
dc.description.abstractFormulation of a fast-disintegrating drug delivery system from cyclodextrin/naproxen inclusion complex nanofibrous films Naproxen is a well-known non-steroidal anti-inflammatory drug (NSAID) that suffers from limited water solubility. The inclusion complexation with cyclodextrin (CD) can eliminate this drawback and the free-standing nanofibrous film (NF) generated from these inclusion complexes (ICs) can be a promising alternative formula as an orally disintegrating drug delivery system. For this, naproxen/CD IC NFs were generated using the highly water soluble hydroxypropylated derivative of βCD (HPβCD) with two different molar ratios of 1/1 and 1/2 (drug/CD). The complexation energy calculated by the modeling study demonstrated a more favorable interaction between HPβCD and naproxen for the 1/2 molar ratio than 1/1. HPβCD/naproxen IC NFs were generated with loading concentrations of ∼7–11% and without using toxic chemicals. HPβCD/naproxen IC NFs indicated a faster and enhanced release profile in aqueous medium compared to pure naproxen owing to inclusion complexation. Moreover, rapid disintegration in less than a second was achieved in an artificial saliva environment.
dc.description.provenanceMade available in DSpace on 2024-03-22T12:46:50Z (GMT). No. of bitstreams: 1 Formulation_of_a_fast-disintegrating_drug_delivery_system_from_cyclodextrin_naproxen_inclusion_complex_nanofibrous_films.pdf: 667249 bytes, checksum: e840ecf9e4e893e5782d353d4bc20d6e (MD5) Previous issue date: 2023-12-21en
dc.identifier.doi10.1039/D3MD00557G
dc.identifier.eissn2632-8682
dc.identifier.urihttps://hdl.handle.net/11693/115087
dc.language.isoen_US
dc.publisherRoyal Society of Chemistry
dc.relation.isversionofhttps://doi.org/10.1039/D3MD00557G
dc.rightsCC BY-NC 4.0 Deed (Attribution-NonCommercial 4.0 International)
dc.rights.urihttps://creativecommons.org/licenses/by-nc/2.0/
dc.source.titleRSC Medicinal Chemistry
dc.titleFormulation of a fast-disintegrating drug delivery system from cyclodextrin/naproxen inclusion complex nanofibrous films
dc.typeArticle

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