Nanoparticle labeling: a new era in vivo tracing the cells in liver studies
Date
2012-04
Editor(s)
Advisor
Supervisor
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Instructor
Source Title
Journal of Hepatology
Abstracts of the International Liver Congress 2012: 47th Annual Meeting of the European Association for the Study of the Liver
Abstracts of the International Liver Congress 2012: 47th Annual Meeting of the European Association for the Study of the Liver
Print ISSN
0168-8278
Electronic ISSN
Publisher
Elsevier
Volume
56
Issue
Supplement 2
Pages
162 - 163
Language
English
Type
Journal Title
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Volume Title
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Abstract
Tracking molecules in vivo has always been challenging and there is increasing demand for tools that allow researchers to trace especially during cell-based therapies. Conjugated polymer based water-dispersible nanoparticles (NP) represent a new class of probes for cell imaging and tracking because they offer high brightness, improved photostability, high fluorescent quantum yield and non-cytotoxicity comparing to conventional dyes. We aimed to develop a novel approach by using fluorescein emitting NP to label Mesenchymal Stem Cells (MSCs) and HUH7 cell lines and assess their fate in vivo in liver regeneration, liver fibrosis and xenografts.