The Association between familial risk and brain abnormalities Is disease specific: an ENIGMA-relatives study of schizophrenia and bipolar disorder

buir.contributor.authorToulopoulou, Timothea
dc.citation.epage556en_US
dc.citation.issueNumber7en_US
dc.citation.spage545en_US
dc.citation.volumeNumber86en_US
dc.contributor.authorZwarte, S. M. C.en_US
dc.contributor.authorBrouwer, R. M.en_US
dc.contributor.authorAgartz, I.en_US
dc.contributor.authorAlda, M.en_US
dc.contributor.authorAleman, A.en_US
dc.contributor.authorAlpert, K. I.en_US
dc.contributor.authorBearden, C. E.en_US
dc.contributor.authorBertolino, A.en_US
dc.contributor.authorBois, C.en_US
dc.contributor.authorBonvino, A.en_US
dc.contributor.authorBramon, E.en_US
dc.contributor.authorBuimer, E.en_US
dc.contributor.authorCahn, W.en_US
dc.contributor.authorCannon, D. M.en_US
dc.contributor.authorCannon, T. D.en_US
dc.contributor.authorCaseras, X.en_US
dc.contributor.authorCastro-Fornieles, J.en_US
dc.contributor.authorChen, Q.en_US
dc.contributor.authorSerna, E.en_US
dc.contributor.authorGiorgio, A. D.en_US
dc.contributor.authorDoucet, G.en_US
dc.contributor.authorEker, M. C.en_US
dc.contributor.authorErk, S.en_US
dc.contributor.authorFears, S.en_US
dc.contributor.authorFoley, S.en_US
dc.contributor.authorFrangou, S.en_US
dc.contributor.authorFrankland, A.en_US
dc.contributor.authorFullerton, J.en_US
dc.contributor.authorGlahn, D.en_US
dc.contributor.authorGoghari, V.en_US
dc.contributor.authorGoldman, A.en_US
dc.contributor.authorGonul, A.en_US
dc.contributor.authorGruber, O.en_US
dc.contributor.authorHaan, L.en_US
dc.contributor.authorHajek, T.en_US
dc.contributor.authorHawkins, E.en_US
dc.contributor.authorHeinz, A.en_US
dc.contributor.authorHillegers, M.en_US
dc.contributor.authorPol, H.en_US
dc.contributor.authorHultman, C.en_US
dc.contributor.authorIngvar, M.en_US
dc.contributor.authorJohansson, V.en_US
dc.contributor.authorJönsson, E.en_US
dc.contributor.authorKane, K.en_US
dc.contributor.authorKempton, M.en_US
dc.contributor.authorKoenis, M.en_US
dc.contributor.authorKopecek, M.en_US
dc.contributor.authorKrabbendam, L.en_US
dc.contributor.authorKrämer, B.en_US
dc.contributor.authorLawrie, S.en_US
dc.contributor.authorLenroot, R.en_US
dc.contributor.authorMarcelis, M.en_US
dc.contributor.authorMarsman, J-Ben_US
dc.contributor.authorMattay, V.en_US
dc.contributor.authorMcDonald, C.en_US
dc.contributor.authorMeyer-Lindenberg, A.en_US
dc.contributor.authorMichielse, S.en_US
dc.contributor.authorMitchell, P.en_US
dc.contributor.authorMoreno, D.en_US
dc.contributor.authorMurray, R.en_US
dc.contributor.authorMwangi, B.en_US
dc.contributor.authorNajt, P.en_US
dc.contributor.authorNeilson, E.en_US
dc.contributor.authorNewport, J.en_US
dc.contributor.authorOs, J.en_US
dc.contributor.authorOvers, B.en_US
dc.contributor.authorÖzerdem, A.en_US
dc.contributor.authorPicchioni, M.en_US
dc.contributor.authorRichter, A.en_US
dc.contributor.authorRoberts, G.en_US
dc.contributor.authorAydoğan, A. S.en_US
dc.contributor.authorSchofield, P.en_US
dc.contributor.authorŞimşek, F.en_US
dc.contributor.authorSoares, J.en_US
dc.contributor.authorSugranyes, G.en_US
dc.contributor.authorToulopoulou, Timotheaen_US
dc.contributor.authorTronchin, G.en_US
dc.contributor.authorWalter, H.en_US
dc.contributor.authorWang, L.en_US
dc.contributor.authorWeinberger, D.en_US
dc.contributor.authorWhalley, H.en_US
dc.contributor.authorYalın, N.en_US
dc.contributor.authorAndreassen, O.en_US
dc.contributor.authorChing, C.en_US
dc.contributor.authorErp, T.en_US
dc.contributor.authorTurner, J.en_US
dc.contributor.authorJahanshad, N.en_US
dc.contributor.authorThompson, P.en_US
dc.contributor.authorKahn, R.en_US
dc.contributor.authorHaren, N.en_US
dc.date.accessioned2020-01-27T12:44:29Z
dc.date.available2020-01-27T12:44:29Z
dc.date.issued2019
dc.departmentDepartment of Psychologyen_US
dc.description.abstractAbstract Background Schizophrenia and bipolar disorder share genetic liability, and some structural brain abnormalities are common to both conditions. First-degree relatives of patients with schizophrenia (FDRs-SZ) show similar brain abnormalities to patients, albeit with smaller effect sizes. Imaging findings in first-degree relatives of patients with bipolar disorder (FDRs-BD) have been inconsistent in the past, but recent studies report regionally greater volumes compared with control subjects. Methods We performed a meta-analysis of global and subcortical brain measures of 6008 individuals (1228 FDRs-SZ, 852 FDRs-BD, 2246 control subjects, 1016 patients with schizophrenia, 666 patients with bipolar disorder) from 34 schizophrenia and/or bipolar disorder family cohorts with standardized methods. Analyses were repeated with a correction for intracranial volume (ICV) and for the presence of any psychopathology in the relatives and control subjects. Results FDRs-BD had significantly larger ICV (d = +0.16, q < .05 corrected), whereas FDRs-SZ showed smaller thalamic volumes than control subjects (d = −0.12, q < .05 corrected). ICV explained the enlargements in the brain measures in FDRs-BD. In FDRs-SZ, after correction for ICV, total brain, cortical gray matter, cerebral white matter, cerebellar gray and white matter, and thalamus volumes were significantly smaller; the cortex was thinner (d < −0.09, q < .05 corrected); and third ventricle was larger (d = +0.15, q < .05 corrected). The findings were not explained by psychopathology in the relatives or control subjects. Conclusions Despite shared genetic liability, FDRs-SZ and FDRs-BD show a differential pattern of structural brain abnormalities, specifically a divergent effect in ICV. This may imply that the neurodevelopmental trajectories leading to brain anomalies in schizophrenia or bipolar disorder are distinct.en_US
dc.identifier.doi10.1016/j.biopsych.2019.03.985en_US
dc.identifier.issn0006-3223
dc.identifier.urihttp://hdl.handle.net/11693/52842
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttps://dx.doi.org/10.1016/j.biopsych.2019.03.985en_US
dc.source.titleBiological Psychiatryen_US
dc.subjectBipolar disorderen_US
dc.subjectFamilial riskImagingen_US
dc.subjectMeta-analysisen_US
dc.subjectNeurodevelopmenten_US
dc.subjectSchizophreniaen_US
dc.titleThe Association between familial risk and brain abnormalities Is disease specific: an ENIGMA-relatives study of schizophrenia and bipolar disorderen_US
dc.typeReporten_US
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