Collagen-chitosan scaffold modified with Au and Ag nanoparticles: synthesis and structure

Date
2016
Advisor
Instructor
Source Title
Applied Surface Science
Print ISSN
0169-4332
Electronic ISSN
1873-5584
Publisher
Elsevier B.V.
Volume
366
Issue
Pages
365 - 371
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
Abstract

Nowadays, the dermal biomimetic scaffolds are widely used in regenerative medicine. Collagen-chitosan scaffold one of these materials possesses antibacterial activity, good compatibility with living tissues and has been already used as a wound-healing material. In this article, collagen-chitosan scaffolds modified with Ag and Au nanoparticles have been synthesized using novel method - the metal-vapor synthesis. The nanocomposite materials are characterized by XPS, TEM, SEM and synchrotron radiation-based X-ray techniques. According to XRD data, the mean size of the nanoparticles (NPs) is 10.5 nm and 20.2 nm in Au-Collagen-Chitosan (Au-CollCh) and Ag-Collagen-Chitosan (Ag-CollCh) scaffolds, respectively in fair agreement with the TEM data. SAXS analysis of the composites reveals an asymmetric size distribution peaked at 10 nm for Au-CollCh and 25 nm for Ag-CollCh indicative of particle's aggregation. According to SEM data, the metal-carrying scaffolds have layered structure and the nanoparticles are rather uniformly distributed on the surface material. XPS data indicate that the metallic nanoparticles are in their unoxidized/neutral states and dominantly stabilized within the chitosan-rich domains.

Course
Other identifiers
Book Title
Keywords
Collagen-chitosan scaffolds, Metal-vapor synthesis, Nanoparticles, SAXS, XANES/EXAFS, XPS, XRD
Citation
Published Version (Please cite this version)