Dielectric trapping of biopolymers translocating through insulating membranes

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buir.contributor.authorBüyükdağlı, Şahin
dc.citation.epage1242-20en_US
dc.citation.issueNumber11en_US
dc.citation.spage1242-1en_US
dc.citation.volumeNumber10en_US
dc.contributor.authorBüyükdağlı, Şahinen_US
dc.contributor.authorSarabadani, J.en_US
dc.contributor.authorAla-Nissila, T.en_US
dc.date.accessioned2019-02-21T16:08:55Z
dc.date.available2019-02-21T16:08:55Z
dc.date.issued2018en_US
dc.departmentDepartment of Physicsen_US
dc.description.abstractSensitive sequencing of biopolymers by nanopore-based translocation techniques requires an extension of the time spent by the molecule in the pore. We develop an electrostatic theory of polymer translocation to show that the translocation time can be extended via the dielectric trapping of the polymer. In dilute salt conditions, the dielectric contrast between the low permittivity membrane and large permittivity solvent gives rise to attractive interactions between the cis and trans portions of the polymer. This self-attraction acts as a dielectric trap that can enhance the translocation time by orders of magnitude. We also find that electrostatic interactions result in the piecewise scaling of the translocation time t with the polymer length L. In the short polymer regime L ≲ 10 nm where the external drift force dominates electrostatic polymer interactions, the translocation is characterized by the drift behavior τ ~ L2. In the intermediate length regime 10 nm. ≲ L ≲ kb -1 where kb is the Debye-Hückel screening parameter, the dielectric trap takes over the drift force. As a result, increasing polymer length leads to quasi-exponential growth of the translocation time. Finally, in the regime of long polymers L ≳ kb -1 where salt screening leads to the saturation of the dielectric trap, the translocation time grows linearly as τ ~ L. This strong departure from the drift behavior highlights the essential role played by electrostatic interactions in polymer translocation.
dc.description.provenanceMade available in DSpace on 2019-02-21T16:08:55Z (GMT). No. of bitstreams: 1 Bilkent-research-paper.pdf: 222869 bytes, checksum: 842af2b9bd649e7f548593affdbafbb3 (MD5) Previous issue date: 2018en
dc.description.sponsorshipFunding: This research was funded by the Academy of Finland QTF Centre of Excellence program (project 312298).
dc.identifier.doi10.3390/polym10111242
dc.identifier.issn2073-4360
dc.identifier.urihttp://hdl.handle.net/11693/50437
dc.language.isoEnglish
dc.publisherMDPI AG
dc.relation.isversionofhttps://doi.org/10.3390/polym10111242
dc.relation.project312298
dc.rightsinfo:eu-repo/semantics/openAccess
dc.source.titlePolymersen_US
dc.subjectCharge screeningen_US
dc.subjectDielectric membranesen_US
dc.subjectElectrostatic interactionsen_US
dc.subjectPolymer translocationen_US
dc.titleDielectric trapping of biopolymers translocating through insulating membranesen_US
dc.typeArticleen_US

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