G-network modelling based abnormal pathway detection in gene regulatory networks

Simple item page
dc.citation.epage263en_US
dc.citation.spage257en_US
dc.contributor.authorKim H.en_US
dc.contributor.authorAtalay, Rengülen_US
dc.contributor.authorGelenbe, E.en_US
dc.date.accessioned2016-02-08T12:11:43Z
dc.date.available2016-02-08T12:11:43Z
dc.date.issued2012en_US
dc.departmentDepartment of Electrical and Electronics Engineeringen_US
dc.descriptionConference name: 26th International Symposium on Computer and Information Sciencesen_US
dc.description.abstractGene expression centered gene regulatory networks studies can provide insight into the dynamics of pathway activities that depend on changes in their environmental conditions. Thus we propose a new pathway analysis approach to detect differentially behaving pathways in abnormal conditions based on G-network theory. Using this approach gene regulatory network model parameters are estimated from normal and abnormal samples using optimization techniques with corresponding constraints. We show that in a "p53 network" application, the proposed method effectively detects anomalous activated/inactivated pathways related with MDM2, ATM/ATR and RB1 genes, which could not be observed from previous analyses of gene regulatory network normal and abnormal behaviour. © 2012 Springer-Verlag London Limited.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T12:11:43Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2012en
dc.identifier.doi10.1007/978-1-4471-2155-8_32en_US
dc.identifier.doi10.1007/978-1-4471-2155-8en_US
dc.identifier.urihttp://hdl.handle.net/11693/28121
dc.language.isoEnglishen_US
dc.publisherSpringer, Londonen_US
dc.relation.isversionofhttps://doi.org/10.1007/978-1-4471-2155-8_32en_US
dc.relation.isversionofhttps://doi.org/10.1007/978-1-4471-2155-8en_US
dc.source.titleComputer and Information Sciences IIen_US
dc.subjectAbnormal behavioursen_US
dc.subjectAbnormal conditionsen_US
dc.subjectAbnormal samplesen_US
dc.subjectEnvironmental conditionsen_US
dc.subjectGene regulatory network modelen_US
dc.subjectGene regulatory networksen_US
dc.subjectOptimization techniquesen_US
dc.subjectPathway activitiesen_US
dc.subjectGene expressionen_US
dc.subjectInformation scienceen_US
dc.titleG-network modelling based abnormal pathway detection in gene regulatory networksen_US
dc.typeConference Paperen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
G-network modelling based abnormal pathway detection in gene regulatory networks.pdf
Size:
1.75 MB
Format:
Adobe Portable Document Format
Description:
Full printable version
Download

Collections

Scholarly Publications - Electrical and Electronics Engineering