Synthesis of silica-based nanomaterials and their applications in fluorescent, biological and chemical sensing

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buir.advisorElbüken, Çağlar
dc.contributor.authorBeyazkılıç, Pınar
dc.date.accessioned2018-06-11T12:59:02Z
dc.date.available2018-06-11T12:59:02Z
dc.date.copyright2018-06
dc.date.issued2018-06
dc.date.submitted2018-06-11
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (Ph.D.): Bilkent University, Department of Materials Science and Nanotechnology, İhsan Doğramacı Bilkent University, 2018.en_US
dc.descriptionIncludes bibliographical references (leaves 70-84).en_US
dc.description.abstractThis thesis describes development of nanoparticle-based liquid sensors and coatings for droplet-based bioassays. Liquid sensors were produced from mesostructured (2-50 nm) hybrid silica nanoparticles. Detection of trace trinitrotoluene (TNT) and dopamine in aqueous phase was shown based on uorescence of nanoparticles. Silica nanoparticles were synthesized using a facile one-pot solgel method. Pyrene molecules were hybridized with hydrophobic parts of cetyltrimethylammonium micelles followed by silica growth around micelles. Nanoparticles showed good dispersibility and colloidal stability in water. Pyrene exhibited bright and highly stable emission. Pyrene emission exhibited a rapid, sensitive and visual uorescence quenching against TNT and dopamine. For droplet-based assays, robust superhydrophilic patterned superhydrophobic coatings were developed. Biomolecular adsorption and droplet mixing were shown on coatings which were prepared using sol-gel method followed by ultraviolet/ ozone (UV/O) treatment. Droplet-based biomolecular detection platforms were developed using superhydrophilic patterned superhydrophobic surfaces. Bene tting from con nement and evaporation-induced shrinkage of droplets on wetted patterns, sensitive glucose and DNA detection was demonstrated. Glucose was detected based on enhancement of polydopamine (PDA) emission by hydrogen peroxide (H2O2) produced in glucose oxidation reaction. Detection in evaporating droplets resulted with bright uorescence and high sensitivity for analyte molecules. This was due to droplet evaporation which concentrated molecules and increased reaction rates. Surfaces and nanoparticles developed in this thesis hold great potential for biological and chemical analysis with low sample volumes owing to their simple production, sensitive detection responses and versatility.en_US
dc.description.provenanceSubmitted by Betül Özen (ozen@bilkent.edu.tr) on 2018-06-11T12:59:02Z No. of bitstreams: 1 Pinar_Beyazkilic_Doktora_Tez_10193650.pdf: 5665336 bytes, checksum: de8b9378353d6c72f44049dd0170058e (MD5)en
dc.description.provenanceMade available in DSpace on 2018-06-11T12:59:02Z (GMT). No. of bitstreams: 1 Pinar_Beyazkilic_Doktora_Tez_10193650.pdf: 5665336 bytes, checksum: de8b9378353d6c72f44049dd0170058e (MD5) Previous issue date: 2018-06en
dc.description.statementofresponsibilityby Pınar Beyazkılıç.en_US
dc.embargo.release2021-06-11
dc.format.extentxvi, 84 leaves : charts (some color) ; 30 cmen_US
dc.identifier.itemidB158458
dc.identifier.urihttp://hdl.handle.net/11693/47577
dc.language.isoEnglishen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSilica Nanoparticlesen_US
dc.subjectPyreneen_US
dc.subjectSuperhydrophobicen_US
dc.subjectSuperhydrophilicen_US
dc.subjectGlucoseen_US
dc.subjectDNAen_US
dc.subjectDopamineen_US
dc.titleSynthesis of silica-based nanomaterials and their applications in fluorescent, biological and chemical sensingen_US
dc.title.alternativeSilika nanomalzemelerin sentezi ve floresans tabanlı biyolojik ve kimyasal sensör uygulamalarıen_US
dc.typeThesisen_US
thesis.degree.disciplineMaterials Science and Nanotechnology
thesis.degree.grantorBilkent University
thesis.degree.levelMaster's
thesis.degree.nameMS (Master of Science)

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