Optimizing electrode montages of transcranial direct current stimulation for attentional bias modification in early abstinent methamphetamine users

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buir.contributor.authorKhatibi, Ali
dc.citation.spage907en_US
dc.citation.volumeNumber9en_US
dc.contributor.authorShahbabaie, A.en_US
dc.contributor.authorHatami, J.en_US
dc.contributor.authorFarhoudian, A.en_US
dc.contributor.authorEkhtiari, H.en_US
dc.contributor.authorKhatibi, A.en_US
dc.contributor.authorNitsche, M. A.en_US
dc.date.accessioned2019-02-21T16:08:50Z
dc.date.available2019-02-21T16:08:50Z
dc.date.issued2018en_US
dc.departmentDepartment of Psychologyen_US
dc.departmentInterdisciplinary Program in Neuroscience (NEUROSCIENCE)en_US
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.description.abstractIntroduction: Chronic use of most psychoactive drugs may lead to substance dependence and drug addiction. Drug addiction is a chronically relapsing disorder, and current pharmacological and behavioral therapies are not fully efficient. Attentional bias (AB) is hypothesized to have a causal contribution to substance abuse, addiction development and, maintenance. Transcranial direct current stimulation (tDCS) has been of increasing interest in the past few years as a means for modulating neuroplasticity of the human brain. Although several studies have reported promising therapeutic effects for tDCS in drug abusers, there is no consensus about optimal electrode montages and target brain regions. This study was aimed to compare effectiveness of several electrode montages in modifying AB. Methods and Materials: Ninety early-abstinent methamphetamine users were recruited from several residential drug-rehabilitation centers in Tehran province. They were randomly assigned to six groups with different electrode montages, targeting the left or right dorsolateral prefrontal cortex (DLPFC) as follows: Two conditions with anodal tDCS over the right DLPFC (return electrode placed over the left shoulder or left supraorbital ridge), three conditions with the anode positioned over the left DLPFC (return electrode over the right shoulder, right supraorbital ridge, or contralateral DLPFC), and one sham condition. Active stimulation intensity was 2 mA DC, delivered for 13 min followed by a 20-min rest and another 13 min of stimulation. The probe detection task (PDT) was performed to assess AB. The positive and negative affect scale (PANAS), and the depression anxiety stress scales (DASS) were used to assess baseline affective status before the intervention. Results: Mixed model analysis showed that the left DLPFC/right shoulder and left DLPFC/right DLPFC montages reduced AB toward drug-cues in comparison with sham stimulation. Conclusion: Our findings indicate that anodal stimulation over the left DLPFC reduces AB in methamphetamine users. This study offers promising findings for further studies investigating tDCS as a clinical device to modify AB in drug users.
dc.identifier.doi10.3389/fphar.2018.00907
dc.identifier.issn1663-9812
dc.identifier.urihttp://hdl.handle.net/11693/50433
dc.language.isoEnglish
dc.publisherFrontiers Media S.A.
dc.relation.isversionofhttps://doi.org/10.3389/fphar.2018.00907
dc.rightsinfo:eu-repo/semantics/openAccess
dc.source.titleFrontiers in Pharmacologyen_US
dc.subjectAttentional biasen_US
dc.subjectCravingen_US
dc.subjectDrug addictionen_US
dc.subjectElectrode montageen_US
dc.subjectMethamphetamineen_US
dc.subjectNon-invasive brain stimulation (NIBS)en_US
dc.subjectProbe detection tasken_US
dc.subjectTranscranial direct current stimulation (tDCS)en_US
dc.titleOptimizing electrode montages of transcranial direct current stimulation for attentional bias modification in early abstinent methamphetamine usersen_US
dc.typeArticleen_US

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