Genetics and epigenetics of liver cancer

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buir.contributor.authorÖzen, Çiğdem
buir.contributor.authorYıldız, Gökhan
buir.contributor.authorDağcan, Alper Tunga
buir.contributor.authorÇevik, Dilek
buir.contributor.authorÖrs, Ayşegül
buir.contributor.authorKeleş, Umut
buir.contributor.authorTopel, Hande
buir.contributor.authorÖztürk, Mehmet
dc.citation.epage384en_US
dc.citation.issueNumber4en_US
dc.citation.spage381en_US
dc.citation.volumeNumber30en_US
dc.contributor.authorÖzen, Çiğdemen_US
dc.contributor.authorYıldız, Gökhanen_US
dc.contributor.authorDağcan, Alper Tungaen_US
dc.contributor.authorÇevik, Dileken_US
dc.contributor.authorÖrs, Ayşegülen_US
dc.contributor.authorKeleş, Umuten_US
dc.contributor.authorTopel, Handeen_US
dc.contributor.authorÖztürk, Mehmeten_US
dc.coverage.spatialİstanbul, Turkeyen_US
dc.date.accessioned2016-02-08T09:38:37Z
dc.date.available2016-02-08T09:38:37Z
dc.date.issued2013en_US
dc.departmentGenetics and Biotechnology Research Center (BİLGEN)en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.descriptionConference Name: 15th European Congress on Biotechnology, (ECB15) 2012
dc.descriptionDate of Conference: 23-26 September 2012
dc.description.abstractHepatocellular carcinoma (HCC) represents a major form of primary liver cancer in adults. Chronic infections with hepatitis B (HBV) and C (HCV) viruses and alcohol abuse are the major factors leading to HCC. This deadly cancer affects more than 500,000 people worldwide and it is quite resistant to conventional chemo- and radiotherapy. Genetic and epigenetic studies on HCC may help to understand better its mechanisms and provide new tools for early diagnosis and therapy. Recent literature on whole genome analysis of HCC indicated a high number of mutated genes in addition to well-known genes such as TP53, CTNNB1, AXIN1 and CDKN2A, but their frequencies are much lower. Apart from CTNNB1 mutations, most of the other mutations appear to result in loss-of-function. Thus, HCC-associated mutations cannot be easily targeted for therapy. Epigenetic aberrations that appear to occur quite frequently may serve as new targets. Global DNA hypomethylation, promoter methylation, aberrant expression of non-coding RNAs and dysregulated expression of other epigenetic regulatory genes such as EZH2 are the best-known epigenetic abnormalities. Future research in this direction may help to identify novel biomarkers and therapeutic targets for HCC.en_US
dc.identifier.doi10.1016/j.nbt.2013.01.007en_US
dc.identifier.issn1871-6784
dc.identifier.urihttp://hdl.handle.net/11693/20956
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttps://doi.org/10.1016/j.nbt.2013.01.007en_US
dc.source.titleNew Biotechnologyen_US
dc.subjectChronic infectionen_US
dc.subjectDNA hypomethylationen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectPrimary liver cancersen_US
dc.subjectPromoter methylationen_US
dc.subjectRegulatory genesen_US
dc.subjectTherapeutic targetsen_US
dc.subjectWhole genome analysisen_US
dc.subjectAlkylationen_US
dc.subjectDiseasesen_US
dc.subjectNucleic acidsen_US
dc.subjectVirusesen_US
dc.subjectGene expressionen_US
dc.subjectAXIN1 proteinen_US
dc.subjectCyclin dependent kinase inhibitor 2Aen_US
dc.subjectProtein p53en_US
dc.subjectRegulator proteinen_US
dc.subjectTranscription factor EZH2en_US
dc.subjectUnclassified drugen_US
dc.subjectUntranslated RNAen_US
dc.subjectCancer geneticsen_US
dc.subjectChromosome aberrationen_US
dc.subjectDNA methylationen_US
dc.subjectEpigeneticsen_US
dc.subjectGain of function mutationen_US
dc.subjectGene expression regulationen_US
dc.subjectGene frequencyen_US
dc.subjectGenetic associationen_US
dc.subjectGenome analysisen_US
dc.subjectHepatitis B virusen_US
dc.subjectLiver carcinogenesisen_US
dc.subjectLiver cell carcinomaen_US
dc.subjectLoss of function mutationen_US
dc.subjectNonhumanen_US
dc.subjectPriority journalen_US
dc.subjectPromoter regionen_US
dc.subjectVirus DNA cell DNA interactionen_US
dc.subjectVirus genomeen_US
dc.subjectCarcinomaen_US
dc.subjectGenetic epigenesisen_US
dc.subjectGeneticsen_US
dc.subjectCarcinomaen_US
dc.subjectEpigenesisen_US
dc.subjectEpigenomicsen_US
dc.subjectHumanen_US
dc.subjectLiver neoplasmsen_US
dc.titleGenetics and epigenetics of liver canceren_US
dc.typeArticleen_US
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Genetics and Biotechnology Research Center (BİLGEN)
Department of Molecular Biology and Genetics