Influence of phase function on modeled optical response of nanoparticle-labeled epithelial tissues
dc.citation.issueNumber | 8 | en_US |
dc.citation.volumeNumber | 16 | en_US |
dc.contributor.author | Cihan, C. | en_US |
dc.contributor.author | Arifler, D. | en_US |
dc.date.accessioned | 2016-02-08T09:51:50Z | |
dc.date.available | 2016-02-08T09:51:50Z | |
dc.date.issued | 2011 | en_US |
dc.department | Department of Electrical and Electronics Engineering | en_US |
dc.description.abstract | Metal nanoparticles can be functionalized with biomolecules to selectively localize in precancerous tissues and can act as optical contrast enhancers for reflectance-based diagnosis of epithelial precancer. We carry out Monte Carlo (MC) simulations to analyze photon propagation through nanoparticle-labeled tissues and to reveal the importance of using a proper form of phase function for modeling purposes. We first employ modified phase functions generated with a weighting scheme that accounts for the relative scattering strengths of unlabeled tissue and nanoparticles. To present a comparative analysis, we repeat ourMCsimulations with simplified functions that only approximate the angular scattering properties of labeled tissues. The results obtained for common optical sensor geometries and biologically relevant labeling schemes indicate that the exact form of the phase function used as model input plays an important role in determining the reflectance response and approximating functions often prove inadequate in predicting the extent of contrast enhancement due to labeling. Detected reflectance intensities computed with different phase functions can differ up to ̃60% and such a significant deviation may even alter the perceived contrast profile. These results need to be taken into account when developing photon propagation models to assess the diagnostic potential of nanoparticle-enhanced optical measurements. © 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). | en_US |
dc.description.provenance | Made available in DSpace on 2016-02-08T09:51:50Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2011 | en |
dc.identifier.doi | 10.1117/1.3608999 | en_US |
dc.identifier.issn | 10833668 | |
dc.identifier.uri | http://hdl.handle.net/11693/21841 | |
dc.language.iso | English | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1117/1.3608999 | en_US |
dc.source.title | Journal of Biomedical Optics | en_US |
dc.subject | Epithelial precancer | en_US |
dc.subject | Monte Carlo modeling | en_US |
dc.subject | Nanoparticles | en_US |
dc.subject | Optical sensors | en_US |
dc.subject | Phase function | en_US |
dc.subject | Reflectance | en_US |
dc.subject | Angular scattering | en_US |
dc.subject | Comparative analysis | en_US |
dc.subject | Contrast Enhancement | en_US |
dc.subject | Diagnostic potential | en_US |
dc.subject | Epithelial precancer | en_US |
dc.subject | Epithelial tissue | en_US |
dc.subject | Functionalized | en_US |
dc.subject | Labeling scheme | en_US |
dc.subject | Metal nanoparticles | en_US |
dc.subject | Model inputs | en_US |
dc.subject | Monte Carlo modeling | en_US |
dc.subject | Monte Carlo simulations | en_US |
dc.subject | Optical contrast | en_US |
dc.subject | Optical measurement | en_US |
dc.subject | Optical response | en_US |
dc.subject | Perceived contrast | en_US |
dc.subject | Phase functions | en_US |
dc.subject | Photon propagation | en_US |
dc.subject | Photon propagation model | en_US |
dc.subject | Relative scattering | en_US |
dc.subject | Sensor geometries | en_US |
dc.subject | Simplified functions | en_US |
dc.subject | Weighting scheme | en_US |
dc.subject | Histology | en_US |
dc.subject | Monte Carlo methods | en_US |
dc.subject | Nanoparticles | en_US |
dc.subject | Optical data processing | en_US |
dc.subject | Optical sensors | en_US |
dc.subject | Photons | en_US |
dc.subject | Reflection | en_US |
dc.subject | Tissue | en_US |
dc.subject | gold | en_US |
dc.subject | metal nanoparticle | en_US |
dc.subject | article | en_US |
dc.subject | biological model | en_US |
dc.subject | chemistry | en_US |
dc.subject | computer simulation | en_US |
dc.subject | diagnostic imaging | en_US |
dc.subject | epithelium | en_US |
dc.subject | light | en_US |
dc.subject | Monte Carlo method | en_US |
dc.subject | particle size | en_US |
dc.subject | photon | en_US |
dc.subject | precancer | en_US |
dc.subject | radiation scattering | en_US |
dc.subject | Computer Simulation | en_US |
dc.subject | Diagnostic Imaging | en_US |
dc.subject | Epithelium | en_US |
dc.subject | Gold | en_US |
dc.subject | Light | en_US |
dc.subject | Metal Nanoparticles | en_US |
dc.subject | Models, Biological | en_US |
dc.subject | Monte Carlo Method | en_US |
dc.subject | Particle Size | en_US |
dc.subject | Photons | en_US |
dc.subject | Precancerous Conditions | en_US |
dc.subject | Scattering, Radiation | en_US |
dc.title | Influence of phase function on modeled optical response of nanoparticle-labeled epithelial tissues | en_US |
dc.type | Article | en_US |
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