A novel 20-gene prognostic score in pancreatic adenocarcinoma

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buir.contributor.authorDedeoğlu, Ege
buir.contributor.authorAkbar, Muhammad Waqas
buir.contributor.authorKüçükkaraduman, Barış
buir.contributor.authorİşbilen, Murat
buir.contributor.authorGüre, Ali Osmay
dc.citation.epage19en_US
dc.citation.issueNumber4en_US
dc.citation.spage1en_US
dc.citation.volumeNumber15en_US
dc.contributor.authorDemirkol-Canlı, S.
dc.contributor.authorDedeoğlu, Ege
dc.contributor.authorAkbar, Muhammad Waqas
dc.contributor.authorKüçükkaraduman, Barış
dc.contributor.authorİşbilen, Murat
dc.contributor.authorŞükrüoğlu-Erdoğan, Ö.
dc.contributor.authorKılıç-Erciyas, S.
dc.contributor.authorYazıcı, H.
dc.contributor.authorVural, B.
dc.contributor.authorGüre, Ali Osmay
dc.date.accessioned2021-03-01T12:06:59Z
dc.date.available2021-03-01T12:06:59Z
dc.date.issued2020
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractPancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers. Known risk factors for this disease are currently insufficient in predicting mortality. In order to better prognosticate patients with PDAC, we identified 20 genes by utilizing publically available high-throughput transcriptomic data from GEO, TCGA and ICGC which are associated with overall survival and event-free survival. A score generated based on the expression matrix of these genes was validated in two independent cohorts. We find that this “Pancreatic cancer prognostic score 20 –PPS20” is independent of the confounding factors in multivariate analyses, is dramatically elevated in metastatic tissue compared to primary tumor, and is higher in primary tumors compared to normal pancreatic tissue. Transcriptomic analyses show that tumors with low PPS20 have overall more immune cell infiltration and a higher CD8 T cell/Treg ratio when compared to those with high PPS20. Analyses of proteomic data from TCGA PAAD indicated higher levels of Cyclin B1, RAD51, EGFR and a lower E-cadherin/Fibronectin ratio in tumors with high PPS20. The PPS20 score defines not only prognostic and biological sub-groups but can predict response to targeted therapy as well. Overall, PPS20 is a stronger and more robust transcriptomic signature when compared to similar, previously published gene lists.en_US
dc.description.provenanceSubmitted by Zeynep Aykut (zeynepay@bilkent.edu.tr) on 2021-03-01T12:06:59Z No. of bitstreams: 1 A_novel_20_gene_prognostic_score_in_pancreatic_adenocarcinoma.pdf: 1547295 bytes, checksum: a6a3a32eb09f1e091efa5c7df9ade964 (MD5)en
dc.description.provenanceMade available in DSpace on 2021-03-01T12:06:59Z (GMT). No. of bitstreams: 1 A_novel_20_gene_prognostic_score_in_pancreatic_adenocarcinoma.pdf: 1547295 bytes, checksum: a6a3a32eb09f1e091efa5c7df9ade964 (MD5) Previous issue date: 2020en
dc.identifier.doi10.1371/journal.pone.0231835en_US
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11693/75674
dc.language.isoEnglishen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofhttps://dx.doi.org/10.1371/journal.pone.0231835en_US
dc.source.titlePLoS ONEen_US
dc.titleA novel 20-gene prognostic score in pancreatic adenocarcinomaen_US
dc.typeArticleen_US

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