Design and development of ecm-inspired peptidebased nanostructures for bioengineering and biomedicine

buir.advisorTekinay, Ayşe Begüm
dc.contributor.authorArslan, Elif
dc.date.accessioned2017-08-25T08:30:38Z
dc.date.available2017-08-25T08:30:38Z
dc.date.copyright2017-08
dc.date.issued2017-08
dc.date.submitted2017-08-23
dc.departmentGraduate Program in Materials Science and Nanotechnologyen_US
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (Ph.D.): Bilkent University, Department of Materials Science and Nanotechnology, İhsan Doğramacı Bilkent University, 2017.en_US
dc.descriptionIncludes bibliographical references (leaves 181-202).en_US
dc.description.abstractAdvances in understanding of cell-matrix interactions and the regulation of cellular behaviors through nanobiotechnological tools have presented new perspectives for regenerative medicine. Peptide amphiphiles have been used as building blocks for development of bioactive synthetic nanofiber scaffolds for regenerative medicine applications. Biocompatibility, tailorable characteristics, and mechanical stability as well as bioactivitiy of these peptide nanostructures make them ideal candidates for biomedical applications. To guide natural cellular activities, biomaterials should provide a microenvironment similar to that experienced by cells under natural conditions. The native extracellular matrix (ECM) not only provides a suitable physical environment but also incorporates the necessary set of biochemical and mechanical signals to ensure the normal function of cells, as well as mediating their differentiation, morphogenesis and homeostasis by providing biological, physical, and chemical recognition signals that can trigger specific interactions with cell surface receptors. In this thesis, different ECM-mimetic peptide nanofiber formulations were designed and developed, which were shown to have superior chondrogenic and therapeutic effect on stem cell differentiation in vitro and cartilage regeneration in vivo. Hence, the synthetic peptide nanomaterials harbor great promise in mimicking specific ECM molecules as therapeutic agents and model systems.en_US
dc.description.degreePh.D.en_US
dc.description.statementofresponsibilityby Elif Arslan.en_US
dc.embargo.release2020-08-30
dc.format.extentxxix, 202 leaves : illustrations (some color), charts ; 29 cmen_US
dc.identifier.itemidB156116
dc.identifier.urihttp://hdl.handle.net/11693/33548
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectExtracellular matrixen_US
dc.subjectPeptide nanofiberen_US
dc.subjectMesenchymal stem cellen_US
dc.subjectCartilage regnerationen_US
dc.subjectBioactive scaffolden_US
dc.titleDesign and development of ecm-inspired peptidebased nanostructures for bioengineering and biomedicineen_US
dc.title.alternativeBiyomühendislik ve biyotıp uygulamaları için hücreler arası matriksden esinlenilen peptit nanoyapıların tasarımı ve geliştirilmesien_US
dc.typeThesisen_US
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