Label-Free Biosensing with High Selectivity in Complex Media using Microtoroidal Optical Resonators

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buir.contributor.authorBayındır, Mehmet
dc.citation.volumeNumber5en_US
dc.contributor.authorOzgur, E.en_US
dc.contributor.authorToren P.en_US
dc.contributor.authorAktas O.en_US
dc.contributor.authorHuseyinoglu, E.en_US
dc.contributor.authorBayındır, Mehmeten_US
dc.date.accessioned2016-02-08T09:44:10Z
dc.date.available2016-02-08T09:44:10Z
dc.date.issued2015en_US
dc.departmentDepartment of Physicsen_US
dc.description.abstractAlthough label-free biosensors comprised of optical microcavities inherently possess the capability of resolving molecular interactions at individual level, this extreme sensitivity restricts their convenience for large scale applications by inducing vulnerability towards non-specific interactions that readily occur within complex media. Therefore, the use of optical microresonators for biosensing is mostly limited within strictly defined laboratory conditions, instead of field applications as early detection of cancer markers in blood, or identification of contamination in food. Here, we propose a novel surface modification strategy suitable for but not limited to optical microresonator based biosensors, enabling highly selective biosensing with considerable sensitivity as well. Using a robust, silane-based surface coating which is simultaneously protein resistant and bioconjugable, we demonstrate that it becomes possible to perform biosensing within complex media, without compromising the sensitivity or reliability of the measurement. Functionalized microtoroids are successfully shown to resist nonspecific interactions, while simultaneously being used as sensitive biological sensors. This strategy could pave the way for important applications in terms of extending the use of state-of-the-art biosensors for solving problems similar to the aforementioned.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T09:44:10Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2015en
dc.identifier.doi10.1038/srep13173en_US
dc.identifier.issn20452322
dc.identifier.urihttp://hdl.handle.net/11693/21281
dc.language.isoEnglishen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/srep13173en_US
dc.source.titleScientific Reportsen_US
dc.titleLabel-Free Biosensing with High Selectivity in Complex Media using Microtoroidal Optical Resonatorsen_US
dc.typeArticleen_US

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