Polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and bladder cancer susceptibility in the Turkish population
dc.citation.epage | 464 | en_US |
dc.citation.issueNumber | 8 | en_US |
dc.citation.spage | 459 | en_US |
dc.citation.volumeNumber | 75 | en_US |
dc.contributor.author | Törüner, G. A. | en_US |
dc.contributor.author | Akyerli, C. | en_US |
dc.contributor.author | Uçar, A. | en_US |
dc.contributor.author | Aki, T. | en_US |
dc.contributor.author | Atsu, N. | en_US |
dc.contributor.author | Özen, H. | en_US |
dc.contributor.author | Tez, M. | en_US |
dc.contributor.author | Çetinkaya, M. | en_US |
dc.contributor.author | Özçelik, T. | en_US |
dc.date.accessioned | 2016-02-08T10:34:23Z | |
dc.date.available | 2016-02-08T10:34:23Z | |
dc.date.issued | 2001 | en_US |
dc.department | Department of Molecular Biology and Genetics | en_US |
dc.description.abstract | We investigated the effect of the GSTM1 and GSTT1 null genotypes, and GSTP1 313 A/G polymorphism on bladder cancer susceptibility in a case control study of 121 bladder cancer patients, and 121 age- and sex-matched controls of the Turkish population. The adjusted odds ratio for age, sex, and smoking status is 1.94 [95% confidence intervals (CI) 1.15-3.26] for the GSTM1 null genotype, and 1.75 (95% CI 1.03-2.99) for the GSTP1 313 A/G or G/G genotypes. GSTT1 was shown not to be associated with bladder cancer. Combination of the two high-risk genotypes, GSTM1 null and GSTP1 313 A/G or G/G, revealed that the risk increases to 3.91-fold (95% CI 1.88-8.13) compared with the combination of the low-risk genotypes of these loci. In individuals with the combined risk factors of cigarette smoking and the GSTM1 null genotype, the risk of bladder cancer is 2.81 times (95% CI 1.23-6.35) that of persons who both carry the GSTMl-present genotype and do not smoke. Similarly, the risk is 2.38-fold (95% CI 1.12-4.95) for the combined GSTP1 313 A/G and G/G genotypes and smoking. These findings support the role for the GSTM1 null and the GSTP1 313 AG or GG genotypes in the development of bladder cancer. Furthermore, gene-gene (GSTM1-GSTP1) and gene-environment (GSTMl-smoking, GSTP1-smoking) interactions increase this risk substantially. | en_US |
dc.description.provenance | Made available in DSpace on 2016-02-08T10:34:23Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2001 | en |
dc.identifier.doi | 10.1007/s002040100268 | en_US |
dc.identifier.issn | 0340-5761 | |
dc.identifier.uri | http://hdl.handle.net/11693/24789 | |
dc.language.iso | English | en_US |
dc.publisher | Springer | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1007/s002040100268 | en_US |
dc.source.title | Archives of Toxicology | en_US |
dc.subject | Bladder cancer | en_US |
dc.subject | Gene polymorphism | en_US |
dc.subject | Glutathione transferase | en_US |
dc.subject | Glutathione transferase | en_US |
dc.subject | Genetic polymorphism | en_US |
dc.subject | Genotype | en_US |
dc.subject | Major clinical study | en_US |
dc.subject | Priority journal | en_US |
dc.subject | Turkey (republic) | en_US |
dc.subject | Genetic predisposition to disease | en_US |
dc.subject | Genotype | en_US |
dc.subject | Glutathione S-Transferase pi | en_US |
dc.subject | Glutathione transferase | en_US |
dc.subject | Isoenzymes | en_US |
dc.subject | Male | en_US |
dc.subject | Middle Aged | en_US |
dc.subject | Polymerase Chain Reaction | en_US |
dc.subject | Polymorphism, Genetic | en_US |
dc.subject | Urinary bladder neoplasms | en_US |
dc.title | Polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and bladder cancer susceptibility in the Turkish population | en_US |
dc.type | Article | en_US |
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