Synthesis and anticancer activity evaluation of some benzothiazole-piperazine derivatives

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dc.citation.epage389en_US
dc.citation.issueNumber3en_US
dc.citation.spage382en_US
dc.citation.volumeNumber15en_US
dc.contributor.authorGurdal, E.E.en_US
dc.contributor.authorBuclulgan, E.en_US
dc.contributor.authorDurmaz I.en_US
dc.contributor.authorCetin-Atalay, R.en_US
dc.contributor.authorYarim, M.en_US
dc.date.accessioned2016-02-08T10:24:59Z
dc.date.available2016-02-08T10:24:59Z
dc.date.issued2015en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractSynthesis, characterization and cytotoxic activities of ten benzothiazole-piperazine derivatives were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. Based on the GI50 values of the compounds, most of the benzothiazole-piperazine derivatives are active against HUH-7, MCF-7 and HCT-116 cancer cell lines. Aroyl substituted compounds 1h and 1j were found to be the most active derivatives. In addition, further investigation of compounds 1h and 1j by Hoechst staining and FACS revealed that these compounds cause apoptosis by cell cycle arrest at subG1 phase. © 2015 Bentham Science Publishers.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:24:59Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2015en
dc.identifier.issn18715206
dc.identifier.urihttp://hdl.handle.net/11693/24159
dc.language.isoEnglishen_US
dc.publisherBentham Science Publishers B.V.en_US
dc.source.titleAnti-Cancer Agents in Medicinal Chemistryen_US
dc.subjectAnticanceren_US
dc.subjectApoptosisen_US
dc.subjectBenzothiazoleen_US
dc.subjectCytotoxicityen_US
dc.subjectPiperazineen_US
dc.subjectSulphorhodamine Ben_US
dc.subjectbenzothiazole derivativeen_US
dc.subjectflurouracilen_US
dc.subjectn (4 methyl 1,3 benzothiazol 2 yl) 2 (4 acetylpiperazin 1 yl)acetamideen_US
dc.subjectn (4 methyl 1,3 benzothiazol 2 yl) 2 (4 benzoylpiperazin 1 yl)acetamideen_US
dc.subjectn (4 methyl 1,3 benzothiazol 2 yl) 2 [4 (2 furoyl)piperazin 1 yl]acetamideen_US
dc.subjectn (4 methylbenzothiazol 2 yl) 2 (4 chlorobenzylpiperazin 1 yl)acetamideen_US
dc.subjectn (4 methylbenzothiazol 2 yl) 2 (4 methylpiperazin 1 yl)acetamideen_US
dc.subjectn (4 methylbenzothiazol 2 yl) 2 [1 (4 methylphenyl)piperazine 1 yl)acetamideen_US
dc.subjectn (4 methylbenzothiazol 2 yl) 2 [4 (2 hydroxyphenyl)piperazin 1 yl)]acetamideen_US
dc.subjectn (4 methylbenzothiazol 2 yl) 2 [4 (3,4 dichlorophenyl)piperazin 1 yl]acetamideen_US
dc.subjectn (4 methylbenzothiazol 2 yl) 2 [4 (4 fluorophenyl)piperazin 1 yl]acetamideen_US
dc.subjectn (4 methylbenzothiazol 2 yl) 2 [4 (4 nitrophenyl)piperazin 1 yl]acetamideen_US
dc.subjectpiperazine derivativeen_US
dc.subjectunclassified drugen_US
dc.subjectantineoplastic agenten_US
dc.subjectbenzothiazoleen_US
dc.subjectbenzothiazole derivativeen_US
dc.subjectpiperazineen_US
dc.subjectpiperazine derivativeen_US
dc.subjectantineoplastic activityen_US
dc.subjectapoptosisen_US
dc.subjectArticleen_US
dc.subjectbioassayen_US
dc.subjectcarbon nuclear magnetic resonanceen_US
dc.subjectcell cycle arresten_US
dc.subjectcontrolled studyen_US
dc.subjectcytotoxicityen_US
dc.subjectdrug structureen_US
dc.subjectdrug synthesisen_US
dc.subjectfluorescence activated cell sortingen_US
dc.subjectHoechst stainingen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectinfrared spectroscopyen_US
dc.subjectproton nuclear magnetic resonanceen_US
dc.subjectsulphorhodamine B assayen_US
dc.subjectcell cycleen_US
dc.subjectcell deathen_US
dc.subjectcell proliferationen_US
dc.subjectchemical structureen_US
dc.subjectchemistryen_US
dc.subjectdose responseen_US
dc.subjectdrug effectsen_US
dc.subjectdrug screeningen_US
dc.subjectHCT116 cell lineen_US
dc.subjectMCF 7 cell lineen_US
dc.subjectstructure activity relationen_US
dc.subjectsynthesisen_US
dc.subjecttumor cell cultureen_US
dc.subjectAntineoplastic Agentsen_US
dc.subjectBenzothiazolesen_US
dc.subjectCell Cycleen_US
dc.subjectCell Deathen_US
dc.subjectCell Proliferationen_US
dc.subjectDose-Response Relationship, Drugen_US
dc.subjectDrug Screening Assays, Antitumoren_US
dc.subjectHCT116 Cellsen_US
dc.subjectHumansen_US
dc.subjectMCF-7 Cellsen_US
dc.subjectMolecular Structureen_US
dc.subjectPiperazinesen_US
dc.subjectStructure-Activity Relationshipen_US
dc.subjectTumor Cells, Cultureden_US
dc.titleSynthesis and anticancer activity evaluation of some benzothiazole-piperazine derivativesen_US
dc.typeArticleen_US

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