Development of bioactive peptide nanofibers for intervertebral disc regeneration

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buir.advisorTekinay, Ayşe Begüm
dc.contributor.authorUysal, Özge
dc.date.accessioned2017-08-29T13:44:08Z
dc.date.available2017-08-29T13:44:08Z
dc.date.copyright2017-08
dc.date.issued2017-08
dc.date.submitted2017-08-24
dc.departmentGraduate Program in Neuroscienceen_US
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (M.S.): Bilkent University, Department of Neuroscience, İhsan Doğramacı Bilkent University, 2017.en_US
dc.descriptionIncludes bibliographical references (leaves 69-82).en_US
dc.description.abstractLower back pain (LBP) and neck problems are the most common orthopedic diseases worldwide, and the main reason behind LBP is intervertebral disc degeneration (IVDD). Therefore, specialized therapeutic applications to induce intervertebral disc (IVD) regeneration is a necessity. Here, we report the use of a collagen-mimetic bioactive peptide nanofiber scaffold (Col-PA/E-PA) for the improvement of disc regeneration by recapitulating the structure and function of the natural extracellular matrix (ECM) of intervertebral connective tissue. Following two weeks of degeneration, the bioactive nanofiber scaffold was topically applied and the IVD regeneration process was observed through histochemical analyses. The collagen-mimetic bioactive peptide nanofiber system was found to significantly promote glycosaminoglycan and collagen deposition at the site of injury compared to control nanofiber system and saline groups. In addition, the bioactive scaffold was consistently associated with lower values in degeneration scoring analyses, confirming the functional recovery of the tissue. Overall, the collagen-mimetic peptide nanofiber scaffold was able to prevent the progression of IVD degeneration and provide further functional recovery to the tissue.en_US
dc.description.degreeM.S.en_US
dc.description.statementofresponsibilityby Özge Uysal.en_US
dc.embargo.release2020-08-24
dc.format.extentxx, 82 leaves : illustrations (some color), charts ; 30 cm.en_US
dc.identifier.itemidB156113
dc.identifier.urihttp://hdl.handle.net/11693/33569
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPeptide nanofiberen_US
dc.subjectLower back painen_US
dc.subjectIntervertebral disc degenerationen_US
dc.subjectNeedleen_US
dc.subjectRegenerationen_US
dc.subjectCollagenen_US
dc.titleDevelopment of bioactive peptide nanofibers for intervertebral disc regenerationen_US
dc.title.alternativeIntervertebral disk rejenerasyonu için biyoaktif peptit nanofiberlerin geliştirilmesien_US
dc.typeThesisen_US

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