Concept of T-wave morphology dispersion

The detection of ventricular repolarization abnormalities is widely being done using the QT interval measurements. However, there are both technical and theoretical problems with QT measurements. We propose two robust methods for the quantification of the ventricular repolarization abnormalities: i) The quantification of the inter-lead morphology differences of the T wave (T Wave Morphology Dispersion - TMD) ii) The analysis of the T wave wavefront direction with respect to the QRS complex (Total Cosine R_To_T - TCRT). Sensitivity and specificity of 82% (84%) in supine position and 77% (79%) in standing position were achieved for TMD (TCRT). Both parameters were more reproducible than conventional QT interval based parameters.