Metabolomics approaches in experimental allergic encephalomyelitis

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buir.contributor.authorÇiçek, A. Ercüment
dc.citation.epage100en_US
dc.citation.spage94en_US
dc.citation.volumeNumber314en_US
dc.contributor.authorBattini, B.en_US
dc.contributor.authorBund, C.en_US
dc.contributor.authorMoussallieh, F. M.en_US
dc.contributor.authorÇiçek, A. Ercümenten_US
dc.contributor.authorDe Sèze, J.en_US
dc.contributor.authorNamer, I. J.en_US
dc.date.accessioned2019-02-11T12:13:38Z
dc.date.available2019-02-11T12:13:38Z
dc.date.issued2018en_US
dc.departmentDepartment of Computer Engineeringen_US
dc.description.abstractA myelin basic protein (MBP)-induced experimental allergic encephalomyelitis (EAE) involves paraplegia due to a reversible thoracolumbar spinal cord impairment. The aims of this study were thus to find significant metabolic biomarkers of inflammation and identify the site of inflammation in the central nervous system (CNS) during the acute signs in of the disease using metabolomics. All the EAE samples were associated with higher levels of lactate, ascorbate, glucose and amino acids, and decreased level of N-acetyl-aspartate (NAA) compared to the control group. A decreased NAA level has been particularly shown in lumbar spinal cord in relationship with the clinical signs.en_US
dc.embargo.release2019-01-15en_US
dc.identifier.doi10.1016/j.jneuroim.2017.11.018en_US
dc.identifier.eissn1872-8421
dc.identifier.issn0165-5728
dc.identifier.urihttp://hdl.handle.net/11693/49246
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttps://doi.org/10.1016/j.jneuroim.2017.11.018en_US
dc.source.titleJournal of Neuroimmunologyen_US
dc.subjectMetabolomicsen_US
dc.subjectHRMAS NMRen_US
dc.subjectBiomarkeren_US
dc.subjectEAE modelen_US
dc.subjectMultiple sclerosisen_US
dc.subjectInflammationen_US
dc.titleMetabolomics approaches in experimental allergic encephalomyelitisen_US
dc.typeArticleen_US

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