Graph theory to study complex networks in the brain

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buir.advisorVolpe, Giovanni
dc.contributor.authorMijalkov, Mite
dc.date.accessioned2018-05-16T08:08:53Z
dc.date.available2018-05-16T08:08:53Z
dc.date.copyright2018-04
dc.date.issued2018-04
dc.date.submitted2018-05-15
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (Ph.D.): Bilkent University, Department of Materials Science and Nanotechnology, İhsan Doğramacı Bilkent University, 2018.en_US
dc.descriptionIncludes bibliographical references (leaves 191-216).en_US
dc.description.abstractThe brain is a large-scale, intricate web of neurons, known as the connectome. By representing the brain as a network i.e. a set of nodes connected by edges, one can study its organization by using concepts from graph theory to evaluate various measures. We have developed BRAPH - BRain Analysis using graPH theory, a MatLab, object-oriented freeware that facilitates the connectivity analysis of brain networks. BRAPH provides user-friendly interfaces that guide the user through the various steps of the connectivity analysis, such as, calculating adjacency matrices, evaluating global and local measures, performing group comparisons by non-parametric permutations and assessing the communities in a network. To demonstrate its capabilities, we performed connectivity analyses of structural and functional data in two separate studies. Furthermore, using graph theory, we showed that structural magnetic resonance imaging (MRI) undirected networks of stable mild cognitive impairment (sMCI) subjects, late MCI converters (lMCIc), early MCI converters (eMCIc), and Alzheimer’s Disease (AD) patients show abnormal organization. This is indicated, at global level, by decreases in clustering and transitivity accompanied by increases in path length and modularity and, at nodal level, by changes in nodal clustering and closeness centrality in patient groups when compared to controls. In samples that do not exhibit differences in the undirected analysis, we propose the usage of directed networks to assess any topological changes due to a neurodegenerative disease. We demonstrate that such changes can be identified in Alzheimer’s and Parkinson’s patients by using directed networks built by delayed correlation coefficients. Finally, we put forward a method that improves the reconstruction of the brain connectome by utilizing the delays in the dynamic behavior of the neurons. We show that this delayed correlation method correctly identifies 70% to 80% of the real connections in simulated networks and performs well in the identification of their global and nodal properties.en_US
dc.description.provenanceSubmitted by Betül Özen (ozen@bilkent.edu.tr) on 2018-05-16T08:08:53Z No. of bitstreams: 1 MiteMijalkov_PhDthesis.pdf: 33801637 bytes, checksum: 00e990868c2eae55a9b1a325dc10df37 (MD5)en
dc.description.provenanceMade available in DSpace on 2018-05-16T08:08:53Z (GMT). No. of bitstreams: 1 MiteMijalkov_PhDthesis.pdf: 33801637 bytes, checksum: 00e990868c2eae55a9b1a325dc10df37 (MD5) Previous issue date: 2018-05en
dc.description.statementofresponsibilityby Mite Mijalkov.en_US
dc.embargo.release2021-04-24
dc.format.extentxix, 240, 23 leaves, 14 unnumbered leaves : illustrations (some color), charts (some color) ; 30 cmen_US
dc.identifier.itemidB158317
dc.identifier.urihttp://hdl.handle.net/11693/46935
dc.language.isoEnglishen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGraph theoryen_US
dc.subjectBRAPHen_US
dc.subjectDirected networksen_US
dc.subjectConnectome reconstructionen_US
dc.titleGraph theory to study complex networks in the brainen_US
dc.title.alternativeBeyindeki kompleks ağları analiz etmek için graf teorisien_US
dc.typeThesisen_US
thesis.degree.disciplineMaterials Science and Nanotechnology
thesis.degree.grantorBilkent University
thesis.degree.levelDoctoral
thesis.degree.namePh.D. (Doctor of Philosophy)

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