Spatial learning and memory deficits after whole-brain irradiation are associated with changes in nmda receptor subunits in the hippocampus

Simple item page
buir.contributor.authorAdams, Michelle M.
dc.citation.epage899en_US
dc.citation.issueNumber6en_US
dc.citation.spage892en_US
dc.citation.volumeNumber166en_US
dc.contributor.authorShi, L.en_US
dc.contributor.authorAdams, Michelle M.en_US
dc.contributor.authorLong, A.en_US
dc.contributor.authorCarter, C.en_US
dc.contributor.authorBennett, C.en_US
dc.contributor.authorSonntag, W.en_US
dc.contributor.authorNicolle, M.en_US
dc.contributor.authorRobbins, M.en_US
dc.contributor.authorD'Agostino, R.en_US
dc.contributor.authorBrunso-Bechtold, J.en_US
dc.date.accessioned2020-04-05T15:18:49Z
dc.date.available2020-04-05T15:18:49Z
dc.date.issued2006
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.description.abstractWhole-brain irradiation is used for the treatment of brain tumors, but can it also induce neural changes, with progressive dementia occurring in 20–50% of long-term survivors. The present study investigated whether 45 Gy of whole-brain irradiation delivered to 12-month-old Fischer 344 × Brown Norway rats as nine fractions over 4.5 weeks leads to impaired Morris water maze (MWM) performance 12 months later. Compared to sham-irradiated rats, the irradiated rats demonstrated impaired MWM performance. The relative levels of the NR1 and NR2A but not the NR2B subunits of the NMDA receptor were significantly higher in hippocampal CA1 of irradiated rats compared to control rats. No significant differences were detected for these NMDA subunits in CA3 or dentate gyrus. Further analysis of CA1 revealed that the relative levels of the GluR1 and GluR2 subunits of the AMPA receptor and synaptophysin were not altered by whole-brain irradiation. In summary, a clinically relevant regimen of fractionated whole-brain irradiation led to significant impairments in spatial learning and reference memory and alterations in the relative levels of subunits of the NMDA, but not the AMPA, receptors in hippocampal CA1. These findings suggest for the first time that radiation-induced cognitive impairments may be associated with alterations in glutamate receptor composition.en_US
dc.description.provenanceSubmitted by Onur Emek (onur.emek@bilkent.edu.tr) on 2020-04-05T15:18:49Z No. of bitstreams: 1 Spatial_learning_and_memory_deficits_after_whole-brain_ırradiation_are_associated_with_changes_in_nmda_receptor_subunits_in_the_hippocampus.pdf: 168638 bytes, checksum: 30c8620191ff3606e96a79f03c40d9c8 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-04-05T15:18:49Z (GMT). No. of bitstreams: 1 Spatial_learning_and_memory_deficits_after_whole-brain_ırradiation_are_associated_with_changes_in_nmda_receptor_subunits_in_the_hippocampus.pdf: 168638 bytes, checksum: 30c8620191ff3606e96a79f03c40d9c8 (MD5) Previous issue date: 2006en
dc.identifier.doi10.1667/RR0588.1en_US
dc.identifier.eissn1938-5404
dc.identifier.issn0033-7587
dc.identifier.urihttp://hdl.handle.net/11693/53543
dc.language.isoEnglishen_US
dc.publisherRadiation Research Society.en_US
dc.relation.isversionofhttps://doi.org/10.1667/RR0588.1en_US
dc.source.titleRadiation Researchen_US
dc.titleSpatial learning and memory deficits after whole-brain irradiation are associated with changes in nmda receptor subunits in the hippocampusen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Bilkent-research-paper.pdf
Size:
262.66 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Aysel Sabuncu Brain Research Center (BAM)