Potent stimulation of the innate immune system by nucleic acid based TLR ligands encapsulated in nanoliposomes

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dc.citation.epage133en_US
dc.citation.spage132en_US
dc.contributor.authorBayyurt, Banuen_US
dc.contributor.authorGürsel, İhsanen_US
dc.coverage.spatialMainz, Germanyen_US
dc.date.accessioned2019-07-08T09:55:30Z
dc.date.available2019-07-08T09:55:30Z
dc.date.issued2012-05en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.descriptionConference Name: 10th CIMT Annual Meeting, Towards Next-Generation Cancer Immunotherapy, CIMT 2012en_US
dc.descriptionDate of Conference: 23-25 May 2012en_US
dc.description.abstractNucleic acids with bacterial and viral origins are recognized by toll like receptors (TLRs) that triggers mammalian innate immune system to secrete proinflammatory or inflammatory cytokines. Even though these ligands have a high potency to be used in clinical applications as a vaccine adjuvant or as an immunotherapeutic agent, the rapid clearance from the body by serum proteins, in vivo degradation via nucleases, consequently lead to poor in vivo stability and performance thus hampers their clinical applications.en_US
dc.description.provenanceSubmitted by Zeynep Aykut (zeynepay@bilkent.edu.tr) on 2019-07-08T09:55:30Z No. of bitstreams: 1 Potent_stimulation_of_the_innate_immune_system_by_nucleic_acid_based_TLR_ligands_encapsulated_in_nanoliposomes.pdf: 571743 bytes, checksum: 9341e423362bbe1ab5df78f8638b412b (MD5)en
dc.description.provenanceMade available in DSpace on 2019-07-08T09:55:30Z (GMT). No. of bitstreams: 1 Potent_stimulation_of_the_innate_immune_system_by_nucleic_acid_based_TLR_ligands_encapsulated_in_nanoliposomes.pdf: 571743 bytes, checksum: 9341e423362bbe1ab5df78f8638b412b (MD5) Previous issue date: 2012-05en
dc.identifier.urihttp://hdl.handle.net/11693/52145
dc.language.isoEnglishen_US
dc.publisherAssociation for Cancer Immunotherapyen_US
dc.source.titleAbstract Book 2012, 10th CIMT Annual Meetingen_US
dc.titlePotent stimulation of the innate immune system by nucleic acid based TLR ligands encapsulated in nanoliposomesen_US
dc.typeConference Paperen_US

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