Non-covalently functionalized SWNTs as potential delivery agents for novel BODIPY*based PDT sensitizers & the design and synthesis of dendritic light harvesters

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buir.advisorAkkaya, Engin U.
dc.contributor.authorErbaş, Sündüs
dc.date.accessioned2016-01-08T18:18:45Z
dc.date.available2016-01-08T18:18:45Z
dc.date.issued2009
dc.departmentGraduate Program in Materials Science and Nanotechnologyen_US
dc.descriptionAnkara : The Materials Science and Nanotechnology Program of the Institute of Engineering and Sciences of Bilkent University, 2009.en_US
dc.descriptionThesis (Master's) -- Bilkent University, 2009.en_US
dc.descriptionIncludes bibliographical references.en_US
dc.description.abstractPhotodynamic therapy (PDT) is a non-invasive method used for the treatment of a number of diseases including certain cancers and some cardiovascular diseases. Photodynamic action depends on absorbance of photosensitizer (PS) in near IR region of the spectrum and subsequent generation of cytotoxic singlet oxygen in the vicinity of the PS. Carbon nanotubes are widely used for biomedical applications due to their inertness, biocompatibility, cellular internalization, facile and multi-modification. We have synthesized and characterized novel water soluble boradiazaindacene (BODIPY)-based PS, noncovalently attached on to the single wall carbon nanotube (SWNT). We have observed that near infrared absorbing photosensitizer preserve its singlet oxygen generation capability upon adsorption on SWNT. We have demonstrated that SWNTs can be used as the delivery vehicle of PS for the use in PDT. In the second part of this research, multichromatic cascade-type light harvesting BODIPY dendrimers were synthesized and highly efficient energy transfer was observed. Successful channeling of energy in a predefined region of the dendrimer was revealed.en_US
dc.description.degreeM.S.en_US
dc.description.provenanceMade available in DSpace on 2016-01-08T18:18:45Z (GMT). No. of bitstreams: 1 0006199.pdf: 17451739 bytes, checksum: 4286e4fd00b3fcf7499070ea786b410b (MD5)en
dc.description.statementofresponsibilityErbaş, Sündüsen_US
dc.format.extentxix, 166 leaves, illustrationsen_US
dc.identifier.urihttp://hdl.handle.net/11693/15460
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBoradiazaindaceneen_US
dc.subjectphotodynamic therapyen_US
dc.subjectphotosensitizeren_US
dc.subjectsinglewall cabon nanotubeen_US
dc.subjectlight harvestingen_US
dc.subjectdendrimeren_US
dc.subject.lccTA455.C3 E73 2009en_US
dc.subject.lcshNanotubes, Carbon.en_US
dc.subject.lcshCarbon.en_US
dc.subject.lcshNanostructured materials.en_US
dc.subject.lcshTubes.en_US
dc.subject.lcshPhotochemotherapy.en_US
dc.titleNon-covalently functionalized SWNTs as potential delivery agents for novel BODIPY*based PDT sensitizers & the design and synthesis of dendritic light harvestersen_US
dc.typeThesisen_US

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