Analysis of differentially expressed genes in bipolar disorder: transcriptomic signature of adolescence and young adulthood in working memory-relared area

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buir.advisorToulopoulou, Timothea
dc.contributor.authorŞen, Rabia
dc.date.accessioned2020-12-23T07:44:10Z
dc.date.available2020-12-23T07:44:10Z
dc.date.copyright2020-11
dc.date.issued2020-11
dc.date.submitted2020-12-22
dc.departmentGraduate Program in Neuroscienceen_US
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (M.S.): Bilkent University, Department of Neuroscience, İhsan Doğramacı Bilkent University, 2020.en_US
dc.descriptionIncludes bibliographical references (leaves 33-44).en_US
dc.description.abstractBipolar disorder (BD) is a heritable severe illness. One of the indications of BD is working memory (WM) impairment which is a heritable cognitive trait. The aim of the current study is to identify the transcriptomic level developmental biomarkers of BD in WM-related brain regions. We based our analysis on adolescence and young adulthood (AYA), the critical period for both BD and cognitive development. We have chosen 4 publicly available microarray datasets from Gene Omnibus database for which one is derived from healthy controls and three from bipolar disorder patients. We compared different developmental periods of the brains of normal subjects to determine healthy brain development at the transcriptomic level. After applying the same method to detect bipolar development to show differences between BD and healthy brains. We followed these comparisons in two steps; on gene-level analysis and geneset level analysis. Next, we identified common genes and pathways from the results of different analyses. As a result of this comparison, while six genes were identified differentially expressed, we observed 5 Gene Ontology (GO) genesets shown different regulation patterns in bipolar and healthy brains. The literature review has been shown that the significant biological pathways might be influenced by the treatment.en_US
dc.description.degreeM.S.en_US
dc.description.provenanceSubmitted by Betül Özen (ozen@bilkent.edu.tr) on 2020-12-23T07:44:10Z No. of bitstreams: 1 Rabia_thesis.pdf: 1020990 bytes, checksum: e93548909d3e17d7956d72ce84ba7a33 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-12-23T07:44:10Z (GMT). No. of bitstreams: 1 Rabia_thesis.pdf: 1020990 bytes, checksum: e93548909d3e17d7956d72ce84ba7a33 (MD5) Previous issue date: 2020-12en
dc.description.statementofresponsibilityby Rabia Şenen_US
dc.format.extentix, 42 leaves : illustrations ; 30 cm.en_US
dc.identifier.itemidB125781
dc.identifier.urihttp://hdl.handle.net/11693/54852
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBipolar disorderen_US
dc.subjectBrain developmenten_US
dc.subjectWorking memoryen_US
dc.subjectMicroarray data analysisen_US
dc.titleAnalysis of differentially expressed genes in bipolar disorder: transcriptomic signature of adolescence and young adulthood in working memory-relared areaen_US
dc.title.alternativeBipolar bozuklukta farklı eksprese genlerin analizi: çalışma belleği ile ilgili bölgelerde ergenlik ve genç erişkinliğin transkiptom imzasıen_US
dc.typeThesisen_US

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