Effects of obesity on airway and systemic inflammation in asthmatic children

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buir.contributor.authorGürsel, İhsan
buir.contributor.authorKahraman, Tamer
buir.contributor.orcidKahraman, Tamer|0000-0002-5527-7336
dc.citation.epage689en_US
dc.citation.issueNumber8en_US
dc.citation.spage679en_US
dc.citation.volumeNumber182en_US
dc.contributor.authorVezir, Emine
dc.contributor.authorCivelek, Ersoy
dc.contributor.authorDibek Misirlioglu, Emine
dc.contributor.authorToyran, Muge
dc.contributor.authorCapanoglu, Murat
dc.contributor.authorKarakus, Esra
dc.contributor.authorKahraman, Tamer
dc.contributor.authorOzguner, Meltem
dc.contributor.authorDemirel, Fatma
dc.contributor.authorGürsel, İhsan
dc.contributor.authorKocabas, Can Naci
dc.date.accessioned2022-02-09T07:36:46Z
dc.date.available2022-02-09T07:36:46Z
dc.date.issued2021-03-22
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractObese asthma is a complex syndrome with certain phenotypes that differ in children and adults. There is no clear evidence regarding the presence of additive or synergistic pathological interaction between obesity and asthma in children. Objectives: Our aim was to demonstrate the interaction of obesity and asthma in children in terms of airway and systemic inflammation by a controlled observational study. Methods: Four groups were formed: asthma obese (AO), asthma nonobese (ANO), non-AO (NAO), nonasthma nonobese (NANO). Spirometry test, fractional exhaled nitric oxide (FeNO) test, skin prick test, serum inflammatory biomarkers (C-reactive protein, C3, C4, adiponectin, leptin, resistin, periostin, YKL-40, Type 1, and Type 2 cytokines) were conducted and evaluated in all participants. Sputum inflammatory cells (sputum eosinophils and neutrophils) were evaluated in patients who could produce induced sputum and obesity-asthma interactions were determined. Results: A total of 153 participants aged 6–18 years were included in the study, including the AO group (n = 46), the ANO group (n = 45), the NAO group (n = 30), and the NANO group (n = 32). IL-4 (p < 0.001), IL-5 (p < 0.001), IL-13 (p < 0.001), resistin (p < 0.001), and YKL-40 (p < 0.001) levels were higher in patients with asthma independent of obesity. The lowest adiponectin level was found in the AO group and obesity-asthma interaction was detected (p < 0.001). Sputum eosinophilia (p < 0.01), sputum neutrophilia (p < 0.01), and FeNO levels (p = 0.07) were higher in asthmatic patients independent of obesity. In the group with paucigranulocytic inflammation, resistin and YKL-40 levels were significantly lower than in the group without paucigranulocytic inflammation (p < 0.01). Conclusion: No interaction was found between obesity and asthma in terms of airway inflammation. Interaction between obesity and asthma was shown in terms of adiponectin level and resistin/adiponectin and leptin/adiponectin ratios. It was found that serum YKL-40 and resistin levels could be associated with airway inflammation.en_US
dc.description.provenanceSubmitted by Türkan Cesur (cturkan@bilkent.edu.tr) on 2022-02-09T07:36:46Z No. of bitstreams: 1 Effects_of_obesity_on_airway_and_systemic_inflammation_in_asthmatic_children.pdf: 327941 bytes, checksum: 7d772385e8b7867b1cda28fee88e5265 (MD5)en
dc.description.provenanceMade available in DSpace on 2022-02-09T07:36:46Z (GMT). No. of bitstreams: 1 Effects_of_obesity_on_airway_and_systemic_inflammation_in_asthmatic_children.pdf: 327941 bytes, checksum: 7d772385e8b7867b1cda28fee88e5265 (MD5) Previous issue date: 2021-03-22en
dc.identifier.doi10.1159/000513809en_US
dc.identifier.eissn1423-0097
dc.identifier.issn1018-2438
dc.identifier.urihttp://hdl.handle.net/11693/77150
dc.language.isoEnglishen_US
dc.publisherS. Karger AGen_US
dc.relation.isversionofhttps://doi.org/10.1159/000513809en_US
dc.source.titleInternational Archives of Allergy and Immunologyen_US
dc.subjectAdiponectinen_US
dc.subjectAirway inflammationen_US
dc.subjectAsthmaen_US
dc.subjectChildhooden_US
dc.subjectObesityen_US
dc.subjectSystemic inflammationen_US
dc.titleEffects of obesity on airway and systemic inflammation in asthmatic childrenen_US
dc.typeArticleen_US

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