Rapid relaxation-based color magnetic particle imaging

buir.advisorÇukur, Emine Ülkü Sarıtaş
dc.contributor.authorArslan, Musa Tunç
dc.date.accessioned2022-09-22T13:42:04Z
dc.date.available2022-09-22T13:42:04Z
dc.date.copyright2022-09
dc.date.issued2022-09
dc.date.submitted2022-09-19
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (Ph.D.): Bilkent University, Department of Electrical and Electronics Engineering, İhsan Doğramacı Bilkent University, 2022.en_US
dc.descriptionIncludes bibliographical references (leaves 68-85).en_US
dc.description.abstractMagnetic particle imaging (MPI) is a rapidly developing medical imaging modality that exploits the non-linear response of magnetic nanoparticles (MNPs). Color MPI widens the functionality of MPI, empowering it with the capability to distinguish different MNPs and/or MNP environments. The system function approach for color MPI relies on extensive calibrations that capture the differences in the harmonic responses of the MNPs. An alternative calibration-free x-space-based method called TAURUS (TAU estimation via Recovery of Underlying mirror Symmetry) estimates a map of the relaxation time constant, τ, by recovering the underlying mirror symmetry in the MPI signal. However, TAURUS requires a back and forth scanning of a given region, restricting its usage to slow trajectories with constant or piecewise constant focus fields (FFs). In this thesis, a novel technique is proposed to increase the performance of TAURUS and enable τ map estimation for rapid and multi-dimensional trajectories. The proposed technique is based on correcting the distortions on mirror symmetry induced by time-varying FFs. Simulations and experiments in an in-house MPI scanner demonstrates that the proposed method successfully estimates high-fidelity τ maps for rapid trajectories that provide orders of magnitude reduction in scanning time (over 300 fold for simulations and over 8 fold for experiments) while preserving the calibration-free property of TAURUS. Additionally, the proposed method can successfully map the effective relaxation time constants in a relatively wide field-of-view at frame rates exceeding 5 frames-per-second. This thesis presents the first simulation results demonstrating that the proposed method is capable of generating high fidelity and high frame-rate color MPI images in real time.en_US
dc.description.provenanceSubmitted by Betül Özen (ozen@bilkent.edu.tr) on 2022-09-22T13:42:04Z No. of bitstreams: 1 B161332.pdf: 23439539 bytes, checksum: 40b32c2b7cae2bd0505670b8004801df (MD5)en
dc.description.provenanceMade available in DSpace on 2022-09-22T13:42:04Z (GMT). No. of bitstreams: 1 B161332.pdf: 23439539 bytes, checksum: 40b32c2b7cae2bd0505670b8004801df (MD5) Previous issue date: 2022-09en
dc.description.statementofresponsibilityby Musa Tunç Arslanen_US
dc.format.extentxiii, 85 leaves : illustrations ; 30 cm.en_US
dc.identifier.itemidB161332
dc.identifier.urihttp://hdl.handle.net/11693/110578
dc.language.isoEnglishen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMagnetic particle imagingen_US
dc.subjectColor MPIen_US
dc.subjectNanoparticle relaxationen_US
dc.subjectMirror symmetryen_US
dc.subjectX-space MPIen_US
dc.subjectRapid trajectoryen_US
dc.titleRapid relaxation-based color magnetic particle imagingen_US
dc.title.alternativeHızlı relaksasyon-tabanlı renkli manyetik parçacık görüntülemeen_US
dc.typeThesisen_US
thesis.degree.disciplineElectrical and Electronic Engineering
thesis.degree.grantorBilkent University
thesis.degree.levelDoctoral
thesis.degree.namePh.D. (Doctor of Philosophy)

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