Rapid relaxation-based color magnetic particle imaging
| buir.advisor | Çukur, Emine Ülkü Sarıtaş | |
| dc.contributor.author | Arslan, Musa Tunç | |
| dc.date.accessioned | 2022-09-22T13:42:04Z | |
| dc.date.available | 2022-09-22T13:42:04Z | |
| dc.date.copyright | 2022-09 | |
| dc.date.issued | 2022-09 | |
| dc.date.submitted | 2022-09-19 | |
| dc.description | Cataloged from PDF version of article. | en_US |
| dc.description | Thesis (Ph.D.): Bilkent University, Department of Electrical and Electronics Engineering, İhsan Doğramacı Bilkent University, 2022. | en_US |
| dc.description | Includes bibliographical references (leaves 68-85). | en_US |
| dc.description.abstract | Magnetic particle imaging (MPI) is a rapidly developing medical imaging modality that exploits the non-linear response of magnetic nanoparticles (MNPs). Color MPI widens the functionality of MPI, empowering it with the capability to distinguish different MNPs and/or MNP environments. The system function approach for color MPI relies on extensive calibrations that capture the differences in the harmonic responses of the MNPs. An alternative calibration-free x-space-based method called TAURUS (TAU estimation via Recovery of Underlying mirror Symmetry) estimates a map of the relaxation time constant, τ, by recovering the underlying mirror symmetry in the MPI signal. However, TAURUS requires a back and forth scanning of a given region, restricting its usage to slow trajectories with constant or piecewise constant focus fields (FFs). In this thesis, a novel technique is proposed to increase the performance of TAURUS and enable τ map estimation for rapid and multi-dimensional trajectories. The proposed technique is based on correcting the distortions on mirror symmetry induced by time-varying FFs. Simulations and experiments in an in-house MPI scanner demonstrates that the proposed method successfully estimates high-fidelity τ maps for rapid trajectories that provide orders of magnitude reduction in scanning time (over 300 fold for simulations and over 8 fold for experiments) while preserving the calibration-free property of TAURUS. Additionally, the proposed method can successfully map the effective relaxation time constants in a relatively wide field-of-view at frame rates exceeding 5 frames-per-second. This thesis presents the first simulation results demonstrating that the proposed method is capable of generating high fidelity and high frame-rate color MPI images in real time. | en_US |
| dc.description.provenance | Submitted by Betül Özen (ozen@bilkent.edu.tr) on 2022-09-22T13:42:04Z No. of bitstreams: 1 B161332.pdf: 23439539 bytes, checksum: 40b32c2b7cae2bd0505670b8004801df (MD5) | en |
| dc.description.provenance | Made available in DSpace on 2022-09-22T13:42:04Z (GMT). No. of bitstreams: 1 B161332.pdf: 23439539 bytes, checksum: 40b32c2b7cae2bd0505670b8004801df (MD5) Previous issue date: 2022-09 | en |
| dc.description.statementofresponsibility | by Musa Tunç Arslan | en_US |
| dc.format.extent | xiii, 85 leaves : illustrations ; 30 cm. | en_US |
| dc.identifier.itemid | B161332 | |
| dc.identifier.uri | http://hdl.handle.net/11693/110578 | |
| dc.language.iso | English | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Magnetic particle imaging | en_US |
| dc.subject | Color MPI | en_US |
| dc.subject | Nanoparticle relaxation | en_US |
| dc.subject | Mirror symmetry | en_US |
| dc.subject | X-space MPI | en_US |
| dc.subject | Rapid trajectory | en_US |
| dc.title | Rapid relaxation-based color magnetic particle imaging | en_US |
| dc.title.alternative | Hızlı relaksasyon-tabanlı renkli manyetik parçacık görüntüleme | en_US |
| dc.type | Thesis | en_US |
| thesis.degree.discipline | Electrical and Electronic Engineering | |
| thesis.degree.grantor | Bilkent University | |
| thesis.degree.level | Doctoral | |
| thesis.degree.name | Ph.D. (Doctor of Philosophy) |