PathwayMapper: a collaborative visual web editor for cancer pathways and genomic data

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dc.citation.epage2240en_US
dc.citation.issueNumber14en_US
dc.citation.spage2238en_US
dc.citation.volumeNumber33en_US
dc.contributor.authorBahceci, I.en_US
dc.contributor.authorDogrusoz, U.en_US
dc.contributor.authorLa, K. C.en_US
dc.contributor.authorBabur, O.en_US
dc.contributor.authorGao, J.en_US
dc.contributor.authorSchultz, N.en_US
dc.date.accessioned2018-04-12T11:46:37Z
dc.date.available2018-04-12T11:46:37Z
dc.date.issued2017en_US
dc.departmentDepartment of Computer Engineeringen_US
dc.description.abstractWhile existing network visualization tools enable the exploration of cancer genomics data, most biologists prefer simplified, curated pathway diagrams, such as those featured in many manuscripts from The Cancer Genome Atlas (TCGA). These pathway diagrams typically summarize how a pathway is altered in individual cancer types, including alteration frequencies for each gene. Results: To address this need, we developed the web-based tool PathwayMapper, which runs in most common web browsers. It can be used for viewing pre-curated cancer pathways, or as a graphical editor for creating new pathways, with the ability to overlay genomic alteration data from cBioPortal. In addition, a collaborative mode is available that allows scientists to co-operate interactively on constructing pathways, with support for concurrent modifications and built-in conflict resolution. © 2017 The Author. Published by Oxford University Press. All rights reserved.en_US
dc.description.provenanceMade available in DSpace on 2018-04-12T11:46:37Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2017en
dc.identifier.doi10.1093/bioinformatics/btx149en_US
dc.identifier.issn1367-4803
dc.identifier.urihttp://hdl.handle.net/11693/37644
dc.language.isoEnglishen_US
dc.publisherOxford University Pressen_US
dc.relation.isversionofhttp://dx.doi.org/10.1093/bioinformatics/btx149en_US
dc.source.titleBioinformaticsen_US
dc.titlePathwayMapper: a collaborative visual web editor for cancer pathways and genomic dataen_US
dc.typeArticleen_US

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