Cartilage endplate thickness variation measured by ultrashort echo-time MRI is associated with adjacent disc degeneration

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buir.contributor.authorGündüz Demir, Çiğdem
dc.citation.epageE600en_US
dc.citation.issueNumber10en_US
dc.citation.spageE592en_US
dc.citation.volumeNumber43en_US
dc.contributor.authorBerg-Johansen, B.en_US
dc.contributor.authorHan, M.en_US
dc.contributor.authorFields, A. J.en_US
dc.contributor.authorLiebenberg, E. C.en_US
dc.contributor.authorLim, B. J.en_US
dc.contributor.authorLarson, P. E. Z.en_US
dc.contributor.authorGündüz Demir, Çiğdemen_US
dc.contributor.authorKazakia, G. J.en_US
dc.contributor.authorKrug, R.en_US
dc.contributor.authorLotz, J. C.en_US
dc.date.accessioned2019-02-11T10:50:34Z
dc.date.available2019-02-11T10:50:34Z
dc.date.issued2018en_US
dc.departmentDepartment of Computer Engineeringen_US
dc.departmentInterdisciplinary Program in Neuroscience (NEUROSCIENCE)en_US
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.description.abstractStudy design: A magnetic resonance imaging study of human cadaver spines. Objective: To investigate associations between cartilage endplate (CEP) thickness and disc degeneration. Summary of background data: Damage to the CEP is associated with spinal injury and back pain. However, CEP morphology and its association with disc degeneration have not been well characterized. Methods: Ten lumbar motion segments with varying degrees of disc degeneration were harvested from six cadaveric spines and scanned with MRI in the sagittal plane using a T2-weighted 2D sequence, a 3D ultrashort echo-time (UTE) imaging sequence, and a 3D T1ρ mapping sequence. CEP thicknesses were calculated from 3D UTE image data using a custom, automated algorithm, and these values were validated against histology measurements. Pfirrmann grades and T1ρ values in the disc were assessed and correlated with CEP thickness. Results: The mean CEP thickness calculated from UTE images was 0.74 ± 0.04 mm. Statistical comparisons between histology and UTE-derived measurements of CEP thickness showed significant agreement, with the mean difference not significantly different from zero (p = 0.32). Within-disc variation of T1ρ (standard deviation) was significantly lower for Pfirrmann grade 4 than Pfirrmann grade 3 (p < 0.05). Within-disc variation of T1ρ and adjacent CEP thickness heterogeneity (coefficient of variation) had a significant negative correlation (r = -0.65, p = 0.04). The standard deviation of T1ρand the mean CEP thickness showed a moderate positive correlation (r = 0.40, p = 0.26). Conclusions: This study demonstrates that quantitative measurements of CEP thickness measured from UTE MRI are associated with disc degeneration. Our results suggest that variability in CEP thickness and T1ρ, rather than their mean values, may serve as valuable diagnostic markers for disc degeneration. Level of evidence: N/A.en_US
dc.identifier.doi10.1097/BRS.0000000000002432en_US
dc.identifier.issn0362-2436
dc.identifier.urihttp://hdl.handle.net/11693/49230
dc.language.isoEnglishen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.isversionofhttp://doi.org/10.1097/BRS.0000000000002432en_US
dc.source.titleSpineen_US
dc.subjectCartilage endplateen_US
dc.subjectDisc degenerationen_US
dc.subjectEndplate thicknessen_US
dc.subjectImage processing algorithmen_US
dc.subjectImage segmentationen_US
dc.subjectIntervertebral discen_US
dc.subjectLow back painen_US
dc.subjectLumbar spineen_US
dc.subjectPfirrmann gradeen_US
dc.subjectSpatial variationen_US
dc.subjectT1rhoen_US
dc.subjectUltrashort echo-time MRI (UTE MRI)en_US
dc.titleCartilage endplate thickness variation measured by ultrashort echo-time MRI is associated with adjacent disc degenerationen_US
dc.typeArticleen_US

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Department of Computer Engineering
Aysel Sabuncu Brain Research Center (BAM)