Adenosine regulation of danger signaling

Simple item page
buir.advisorÇekiç, Çağlar
dc.contributor.authorAkdemir, İmran
dc.date.accessioned2017-08-07T09:15:33Z
dc.date.available2017-08-07T09:15:33Z
dc.date.copyright2017-07
dc.date.issued2017-07
dc.date.submitted2017-08-03
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (M.S..): Bilkent University, Department of Molecular Biology and Genetics, İhsan Doğramacı Bilkent University, 2017en_US
dc.descriptionIncludes bibliographical references (leaves 51-55).en_US
dc.description.abstractMetabolic and immune related activities converge as main triggers of adenosine accumulation in extracellular space. Adenosine by engaging adenosine A2A and A2B receptors strongly suppresses innate and adaptive immune responses. Although adenosine receptors are being targeted in preclinical and clinical studies, how different danger signals are regulated by adenosine is poorly understood. Here we showed that adenosine receptor stimulation strongly inhibited inflammatory responses while sparing Type-I interferon responses downstream of different danger signals in dendritic cells and macrophages. Mechanistically, danger signals associated with MyD88-dependent inflammatory pathways such as LPS and CpG but not the danger signals associated with IRF3/Type-I interferon pathways such as pA:U and cGAMP increase the expression of adenosine A2A and A2B receptors. Expression of anti-inflammatory NR4A1 was increased after adenosine receptor stimulation in the presence of TLR ligands known to activate MyD88 pathway but not in the presence of cGAMP and pA:U. Overall these results indicate that there is a differential modulation of danger signaling by adenosine rather than overall suppression. Our results have important implications for developing combinatorial approaches to target adenosine and danger signaling pathways to cure immune-related diseases.en_US
dc.description.degreeM.S.en_US
dc.description.statementofresponsibilityby İmran Akdemir.en_US
dc.embargo.release2020-08-03
dc.format.extentxiii, 60 leaves : illustrations (some color), charts ; 29 cm.en_US
dc.identifier.itemidB156075
dc.identifier.urihttp://hdl.handle.net/11693/33534
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdenosine receptorsen_US
dc.subjectDanger signalingen_US
dc.subjectDendritic cellsen_US
dc.subjectMacrophagesen_US
dc.titleAdenosine regulation of danger signalingen_US
dc.title.alternativeAdenozinin tehlike sinyallerini regülasyonuen_US
dc.typeThesisen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
10159525.pdf
Size:
1.33 MB
Format:
Adobe Portable Document Format
Description:
Full printable version
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Dept. of Molecular Biology and Genetics - Master's degree