Synthesis and cytotoxicity studies of novel benzhydrylpiperazine carboxamide and thioamide derivatives

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dc.citation.epage214en_US
dc.citation.issueNumber2en_US
dc.citation.spage205en_US
dc.citation.volumeNumber29en_US
dc.contributor.authorGurdal, E. E.en_US
dc.contributor.authorDurmaz, I.en_US
dc.contributor.authorCetin Atalay, R.en_US
dc.contributor.authorYarim, M.en_US
dc.date.accessioned2016-02-08T11:03:20Z
dc.date.available2016-02-08T11:03:20Z
dc.date.issued2014en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractSynthesis and cytotoxic activities of 32 benzhydrylpiperazine derivatives with carboxamide and thioamide moieties were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. In general, 4-chlorobenzhydrylpiperazine derivatives were more cytotoxic than other compounds. In addition, thioamide derivatives (6a-g) have higher growth inhibition than their carboxamide analogs. © 2014 Informa UK Ltd. All rights reserved.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T11:03:20Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2014en
dc.identifier.doi10.3109/14756366.2013.765416en_US
dc.identifier.issn1475-6366
dc.identifier.urihttp://hdl.handle.net/11693/26682
dc.language.isoEnglishen_US
dc.publisherInforma Healthcareen_US
dc.relation.isversionofhttp://dx.doi.org/10.3109/14756366.2013.765416en_US
dc.source.titleJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.subjectBenzhydrylpiperazineen_US
dc.subjectCytotoxicityen_US
dc.subjectIsocyanateen_US
dc.subjectIsothiocyanateen_US
dc.subjectSulphorhodamine Ben_US
dc.titleSynthesis and cytotoxicity studies of novel benzhydrylpiperazine carboxamide and thioamide derivativesen_US
dc.typeArticleen_US

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