Differential expression of epigenetic regulatory genes in liver cancer

Date

2012-09

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Abstract

Epigenetic mechanisms are involved in the organization of chromatin structure and global regulation of gene expression [1]. Cancer cells display multiple epigenetic changes including aberrations in the methylation of DNA, expression of non-coding RNA s and posttranslational modifications of histones [1,2]. Epigenetic changes appear to play a major role in liver cancer [3], one of the rare malignancies that can be induced by dietary restriction of methyl donors. Furthermore, global DNA hypomethylation and selective promoter hypermethylation of a large set of genes affect these cancers. Recently, mutations of ARID1a and ARID2 genes involved in chromatin remodeling have also been reported [4], but a systematic study of the status of epigenetic regulatory genes is lacking. Our aim was to identify epigenetic regulatory genes associated with liver cancer.

Source Title

6th Annual Conference of the International Liver Cancer Association, ILCA 2012

Publisher

International Liver Cancer Association

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Citation

Published Version (Please cite this version)

Language

English