Polymorphisms of Glutathione S- transferase genes (GSTM1, GSTP1, and GSTT1) and breast cancer susceptibility in the Turkish population

Abstract

The potential association between the Glutathione S- transferase genes GSTM1, GSTT1, GSTP1 and breast cancer susceptibility was investigated in a case control study of 264 female patients and 233 age-matched controls in the Turkish population. The combined GSTP1 105 Ile/Val or Val/Val genotypes was significantly associated with breast cancer risk in all women (odds ratio OR=1.64, 95% confidence interval CI=1.09-2.47 and in premenopausal women is OR= 2.01, 95% CI=1.06-3.83). Neither GSTM1 nor GSTT1 was found to be associated with breast cancer. Distribution of GSTP1 genotypes was stratified according to body mass index (BMI), age, age at menarche, age at full-term pregnancy, number of fullterm pregnancies, and family history of breast cancer. The association of the combined GSTP1 105 Ile/Val or Val/Val genotypes with breast cancer risk was further exacerbated in women with high BMI (OR=2.12, 95% CI=1.35-3.62), but not with a low BMI (OR=0.78, 95% CI=0.45-1.34). These findings support the role for the combined GSTP1 105 Ile/Val or Val/Val genotypes in the development of breast cancer, particularly with a high BMI.