Design, synthesis and characterization of orthogonal bodipy trimers and progress tpwards a singlet oxygen probe

Simple item page
buir.advisorAkkaya, Engin U.
dc.contributor.authorBila, Jose Luis
dc.date.accessioned2016-04-15T13:52:54Z
dc.date.available2016-04-15T13:52:54Z
dc.date.copyright2015-08
dc.date.issued2015-08
dc.date.submitted2015-09
dc.departmentDepartment of Chemistryen_US
dc.descriptionCataloged from PDF version of thesis.en_US
dc.descriptionIncludes bibliographical references (leaves 63-71).en_US
dc.descriptionThesis (M.S.): Bilkent University, The Department of Chemistry and the Graduate School of Engineering and Science of, 2015.en_US
dc.description.abstractSeveral methods of fighting cancer have been proposed over the years after it was discovered. Photodynamic therapy (PDT) has been part of these methods for many years therefore; too much financial effort has been spent on this field. Since PDT relays on three important components namely: Sensitizer, molecular oxygen and light, our group has worked and published several photosensitizers derived from BODIPY over the years. In this thesis two different ideas to be used in PDT are introduced. First, Heavy atom free orthogonal BODIPY trimmers are introduced for the first time in literature and they are believed to work according to DS-TR principle. Effective singlet oxygen productions were obtained up to 0.53 quantum yields. The second topic is the use of BODIPY and 1,3-DiphenylIsobenzofuran hybrids as a singlet oxygen sensor. This sensor is meant to work based on PeT and ICT mechanisms. No further experimental methods were applied to this molecule after synthesis however; we intend to use it for in-vivo singlet oxygen experiments in the future.en_US
dc.description.degreeM.S.en_US
dc.description.statementofresponsibilityby Jose Luis Bilaen_US
dc.format.extentxii, 110 leaves :charts.en_US
dc.identifier.itemidB151249
dc.identifier.urihttp://hdl.handle.net/11693/28909
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPhotodynamic therapyen_US
dc.subjectsinglet oxygen sensoren_US
dc.subjectDS-TRen_US
dc.subjectBODIPY trimmersen_US
dc.subjectorthogonalen_US
dc.titleDesign, synthesis and characterization of orthogonal bodipy trimers and progress tpwards a singlet oxygen probeen_US
dc.title.alternativeTrimer dik bodipy yapılarının dizayn, sentez ve karakterizasyonu ve singlet oksijen algılayıcısının gelişimien_US
dc.typeThesisen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
JoseLuisBila_tez.pdf
Size:
6.44 MB
Format:
Adobe Portable Document Format
Description:
Full printable version
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Dept. of Chemistry - Master's degree