Self-assembled peptide nanostructures as a versatile tool for fabrication of nanostructured

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buir.advisorGüler, Mustafa Özgür
dc.contributor.authorGarifullin, Ruslan
dc.date.accessioned2016-04-18T05:57:33Z
dc.date.available2016-04-18T05:57:33Z
dc.date.copyright2015-01
dc.date.issued2015-01
dc.date.submitted26-01-2015
dc.descriptionCataloged from PDF version of thesis.en_US
dc.descriptionIncludes bibliographical references (leaves 130-139).en_US
dc.descriptionThesis (Ph. D.): Bilkent University, Materials Science and Nanotechnology Program, İhsan Doğramacı Bilkent University, 2015.en_US
dc.description.abstractSeveral peptides such as amyloid like peptides (ALPs) and peptide amphiphiles (PAs) were synthesized by solid phase peptide synthesis technique. These peptides were utilized in fabrication of nanostructured materials. ALPs with amino (Ac-KFFAAK-Am) and carboxylate (Ac-EFFAAE-Am) functional groups were used in growth of titanium dioxide (titania) in solution. On the other hand, PA with amino group (lauryl-VVAGK-Am) was used in growth of titania by atomic layer deposition method. Obtained nanostructured titania in each case was used in construction of dye-sensitized solar cells. Peptide amphiphile with phytochelatin mimetic sequence and adamantyl functionality (ADAc-6-Ahx-GECECECG-Am) was used in noncovalent functionalization of electrospun hydroxypropyl-β-cyclodextrin (HPβCD) mesh; HPβCD mesh functionalized with peptide was further used in metal ion scavenging. PA with sequence lauryl-VVAGH-Am was used in noncovalent encapsulation of zinc phthalocyanine derivative. New photophysical properties of encapsulated chromophore were studied and ultrafast energy transfer was observed. L and D peptide amphiphiles (L/D-pyrenebutyryl-6-Ahx-VVAGH-Am and L/D-lauryl-VVAGH-Am) were used to induce chiral organization of achiral chromophore (pyrene) in self-assembled nanofibers of PAs. Two strategies were involved to induce chiral organization: first strategy envisioned conjugation of pyrene to peptide sequence, whereas second strategy involved direct encapsulation of the chromophore. Achiral pyrene molecules organized in supramolecular chiral manner were observed to demonstrate circular dichroism.en_US
dc.description.provenanceSubmitted by Betül Özen (ozen@bilkent.edu.tr) on 2016-04-18T05:57:33Z No. of bitstreams: 1 SELF-ASSEMBLED PEPTIDE NANOSTRUCTURES AS A VERSATILE TOOL FOR FABRICATION OF NANOSTRUCTURED MATERIALS .pdf: 9232134 bytes, checksum: dca039e3a9cc314694fb3f5336885572 (MD5)en
dc.description.provenanceMade available in DSpace on 2016-04-18T05:57:33Z (GMT). No. of bitstreams: 1 SELF-ASSEMBLED PEPTIDE NANOSTRUCTURES AS A VERSATILE TOOL FOR FABRICATION OF NANOSTRUCTURED MATERIALS .pdf: 9232134 bytes, checksum: dca039e3a9cc314694fb3f5336885572 (MD5) Previous issue date: 2015-01en
dc.description.statementofresponsibilityby Ruslan Garifullinen_US
dc.format.extentxx, 139 leaves : charts.en_US
dc.identifier.itemidB149476
dc.identifier.urihttp://hdl.handle.net/11693/28914
dc.language.isoEnglishen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPeptideen_US
dc.subjectBio-inspired mineralizationen_US
dc.subjectNanostructured materialsen_US
dc.subjectProgrammed self-assemblyen_US
dc.subjectOne-dimensional nanostructuresen_US
dc.subjectTemplate directed synthesisen_US
dc.subjectNanotechnologyen_US
dc.titleSelf-assembled peptide nanostructures as a versatile tool for fabrication of nanostructureden_US
dc.title.alternativeKendiliğinden düzenlenen peptit nanoyapıların nanomalzeme üretiminde çok yönlü kullanılmasıen_US
dc.typeThesisen_US
thesis.degree.disciplineMaterials Science and Nanotechnology
thesis.degree.grantorBilkent University
thesis.degree.levelDoctoral
thesis.degree.namePh.D. (Doctor of Philosophy)

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